{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T08:26:18Z","timestamp":1793348778660,"version":"4.5.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As China undergoes a demographic transition towards an aging society, the prevalence and incidence of age-related disabilities, Alzheimer's disease, and various geriatric syndromes are steadily rising.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The China Healthy Aging Cohort Study (China-Aging) aims to investigate the prevalence and associated risk factors of disability and cognitive impairment, and to develop predictive models for these conditions by combining traditional risk factors with artificial intelligence-derived metrics (such as gait, speech, vision, etc.).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The China-Aging cohort consists of community-dwelling participants aged 60 years and older from Beijing, Hangzhou, Shenzhen, and Haikou. The baseline recruitment was from May 16, 2022 to March 19, 2025, with study participants primarily from urban areas. Follow-up assessment of the cohort will occur every 1\u20133 years from the baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 6283 participants who completed the baseline evaluation (mean age 70.6 years, SD 6.3), 3775 (60.1%) were women. The overall prevalence of disability, cognitive impairment, frailty, depression, and sarcopenia were 17.8%, 18.5%, 5.9%, 7.1%, and 5.7%, respectively. The prevalence of disability in the Beijing cohort was higher than in other cohorts (Beijing: 35.6%, Hangzhou: 6.5%, Shenzhen: 6.8%, Haikou: 10.9%) and the prevalence of cognitive impairment in the Haikou cohort was higher than in other cohorts (Beijing: 9.5%, Hangzhou: 7.9%, Shenzhen: 16.2%, Haikou: 45.5%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prevalence of disability and cognitive impairment is relatively high, and notable regional difference exists in China. China-Aging cohort provides crucial evidence for the precise prevention and management of disability, cognitive impairment, and other geriatric syndromes in promoting active and healthy aging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251360028","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T07:12:32Z","timestamp":1752563552000},"page":"348-360","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Cohort profile: China healthy aging cohort study (China-Aging)"],"prefix":"10.1177","volume":"107","author":[{"given":"Jie","family":"Chang","sequence":"first","affiliation":[{"name":"National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing Geriatric Healthcare and Disease Prevention Center, Xuanwu Hospital, Capital Medical University, Beijing, China"},{"name":"Evidence-Based Medicine Center, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; 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