{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:59:17Z","timestamp":1790283557941,"version":"4.1.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Scientific research project of Jiangsu Provincial Health Commission","award":["M2022009"],"award-info":[{"award-number":["M2022009"]}]},{"name":"Nanjing Health Science and Technology Development Special Fund Project","award":["YKK22216"],"award-info":[{"award-number":["YKK22216"]}]},{"name":"Nanjing Health Science and Technology Development Special Fund Project","award":["ZKX23061"],"award-info":[{"award-number":["ZKX23061"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Subjective cognitive decline (SCD) is recognized as an early phase in the progression of Alzheimer's disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the abnormal patterns of morphological and functional connectivity coupling (MC-FC coupling) and their potential diagnostic significance in SCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The data of 52 individuals with SCD and 51 age-gender-education matched healthy controls (HC) who underwent resting-state functional magnetic resonance imaging and high-resolution 3D T\n                      <jats:sub>1<\/jats:sub>\n                      -weighted imaging were retrieved to build the MC and FC of gray matter. Support vector machine (SVM) methods were used for differentiating between SCD and HC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SCD individuals exhibited MC-FC decoupling in the frontoparietal network compared with HC (p\u2009=\u20090.002, 5000 permutations). Using these adjusted MC-FC coupling metrics, SVM analysis achieved 74.76% accuracy, 64.71% sensitivity, and 92.31% specificity (p\u2009&lt;\u20090.001, 5000 permutations). Additionally, the stronger MC-FC coupling of the left inferior temporal gyrus (r\u2009=\u20090.294, p\u2009=\u20090.034) and right posterior cingulate gyrus (r\u2009=\u20090.372, p\u2009=\u20090.007) in SCD individuals was positively correlated with subjective memory complaint performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings of this study provide insight into the idiosyncratic feature of brain organization underlying SCD from the prospective of MC-FC coupling and highlight the potential of MC-FC coupling for the identification of the preclinical stage of AD.<\/jats:p>\n                  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