{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:40:33Z","timestamp":1793320833915,"version":"4.5.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG066511"],"award-info":[{"award-number":["P30AG066511"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Hippocampal atrophy is a key feature of Alzheimer's disease (AD), but neuroimaging is often inaccessible in low-resource settings. Blood-based biomarkers such as amyloid-\u03b2 (A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      ), phosphorylated tau-181 (p-tau181), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP) may offer a practical alternative, though their utility in African populations remains understudied.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study investigated the ability of plasma biomarkers of AD and AD-related dementias\u2014A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      , p-tau181, NfL, and GFAP\u2014to predict hippocampal atrophy in older adults in Kinshasa, Democratic Republic of Congo.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eighty-five adults aged over 65 (40 healthy; 45 suspected AD) were recruited. Core AD (A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      , p-tau181) and non-specific (NfL, GFAP) biomarkers were analyzed. Hippocampal volumes were measured using MRI. Linear and logistic regressions assessed biomarker differences by age, sex, and neurological status, and predicted hippocampal atrophy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Elevated p-tau181 was associated with left hippocampal (LH) atrophy (p\u2009=\u20090.020), with 4.2-fold increased odds [OR\u2009=\u20094.2 (1.5\u201318.4)] of LH atrophy per standard deviation increase. The areas under the curve of plasma biomarkers without clinical covariates to discriminate LH, right hippocampal (RH), and total hippocampal (TH) atrophy ranged from 90%\u201394%, 76%\u201382%, and 85%\u201387%, respectively. Models including clinical covariates and biomarkers improved discrimination to 94%\u201396% (LH), 81%\u201384% (RH), and 88%\u201390% (TH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Consistent with findings from other settings, core AD plasma biomarkers can effectively predict hippocampal atrophy in a Sub-Saharan African population, supporting their potential for scalable dementia screening where imaging is limited.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251360697","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T06:58:35Z","timestamp":1753858715000},"page":"628-640","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Neurodegenerative plasma biomarkers for prediction of hippocampal atrophy in older adults with suspected Alzheimer's disease in Kinshasa, Democratic Republic of Congo"],"prefix":"10.1177","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8754-733X","authenticated-orcid":false,"given":"Jean","family":"Ikanga","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA, USA"},{"name":"School of Medicine, Kinshasa, Department of Psychiatry, University of Kinshasa and Catholic University of Congo, Kinshasa, Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0125-868X","authenticated-orcid":false,"given":"Kharine","family":"Jean","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5416-1184","authenticated-orcid":false,"given":"Priscilla","family":"Medina","sequence":"additional","affiliation":[{"name":"Department of Psychology, Mercer University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1070-6421","authenticated-orcid":false,"given":"Saranya Sundaram","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA, USA"},{"name":"OneRehab, Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6719-8821","authenticated-orcid":false,"given":"Megan","family":"Schwinne","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Biomedical Informatics, Emory University, Atlanta, GA, 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Catholic University of Congo, Kinshasa, Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Immaculee","family":"Kavugho","sequence":"additional","affiliation":[{"name":"Memory Clinic of Kinshasa, Kinshasa, Kinshasa, Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Mampunza","sequence":"additional","affiliation":[{"name":"School of Medicine, Kinshasa, Department of Psychiatry, University of Kinshasa and Catholic University of Congo, Kinshasa, Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lelo","family":"Mananga","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4061-0837","authenticated-orcid":false,"given":"Charlotte 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