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According to Braak's classic model, the neurodegenerative process in Alzheimer's disease (AD) only affects somatosensory cortices in advanced disease stages; however, the processing of complex sensory stimuli, such as CT-mediated Affective Touch, may be impacted in earlier phases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The present study aimed to assess the behavioral and psychophysiological response to CT-targeted touch in a group of biomarker-tested patients with mild cognitive impairment (MCI) due to AD, compared to a group of age, sex, and education matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The preference for CT-optimal stimulations (3 cm\/s) over non-CT-optimal stimulations (30 cm\/s), in terms of perceived pleasantness, was first assessed in both groups. The behavioral (i.e., perceived pleasantness) and psychophysiological (i.e., heart rate and heart rate variability) responses to 16\u2005min of continuous CT-targeted stimulations were then evaluated. All participants also underwent quantitative sensory testing for the screening of tactile sensitivity, tactile acuity, nociception, and interoception.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Despite both groups rating CT-optimal stimulations as more pleasant than non-CT-optimal ones, MCI patients specifically exhibited an altered response to prolonged CT-targeted stimulations, characterized by a progressive reduction of their perceived pleasantness and by an unvaried Heart Rate Variability. No group-differences emerged in other somatosensory-related functions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A specific multi-level alteration of the pleasant and soothing features of CT-optimal touch was identified as a prodromal marker of AD, providing the first indications of how the CT system degrades in conditions of pathological aging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251362249","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T07:03:43Z","timestamp":1754031823000},"page":"743-754","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Sensitivity and vagal reactivity to C-tactile-mediated affective touch in mild cognitive impairment due to Alzheimer's 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