{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:33:19Z","timestamp":1777397599916,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004844","name":"National Cheng Kung University Hospital","doi-asserted-by":"publisher","award":["NCKUH-11402007"],"award-info":[{"award-number":["NCKUH-11402007"]}],"id":[{"id":"10.13039\/501100004844","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Ministry of Health and Welfare","award":["MOHW 113-2314-B-006-108-"],"award-info":[{"award-number":["MOHW 113-2314-B-006-108-"]}]},{"name":"the Ministry of Health and Welfare","award":["MOHW 113-2321-B-006-018-"],"award-info":[{"award-number":["MOHW 113-2321-B-006-018-"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The risk of intracerebral hemorrhage (ICH) in Alzheimer's disease (AD) patients undergoing anticoagulation (AC) remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This nationwide cohort study assessed ICH risk in AC-treated AD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using Taiwan's National Health Insurance Research Database, we identified 1638 AC-treated AD patients and established four matched cohorts: AD with AC, AD without AC, non-AD with AC, and non-AD without AC. We applied inverse probability of treatment weighting (IPTW) and competing risks regression (CRR) to adjust for confounders and mortality risk. Cox proportional hazards regression estimated ICH risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The ICH incidence per 100 person-years was 2.21 in AD patients with AC, 1.03 without AC, 1.71 in non-AD with AC, and 0.28 in non-AD without AC. After IPTW adjustment, compared to non-AD without AC, AD patients with AC had the highest ICH risk (aHR 1.94, 95% CI: 1.44\u20132.61), followed by non-AD with AC (aHR 1.84, 95% CI: 1.51\u20132.23) and AD without AC (aHR 1.74, 95% CI: 1.42\u20132.11). ICH risk in AC-treated AD patients was comparable to non-AD with AC. Subgroup analysis showed higher ICH risk in females and those with hyperlipidemia, diabetes, heart failure, chronic kidney disease, or cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AD is associated with increased ICH risk, which is further elevated by AC use. These findings highlight the need for individualized risk-benefit evaluation, particularly in high-risk populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251362362","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T06:53:07Z","timestamp":1753685587000},"page":"769-777","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Intracerebral hemorrhage risk in Alzheimer's disease patients on anticoagulants: A nationwide cohort study"],"prefix":"10.1177","volume":"107","author":[{"given":"Che-Hui","family":"Hsiao","sequence":"first","affiliation":[{"name":"Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-En","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien-Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren-Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Ju","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Hsiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan"},{"name":"Department of Public Health, College of Medicine, National Cheng-Kung University, Tainan, Taiwan"},{"name":"Biostatistics Consulting Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2505-7583","authenticated-orcid":false,"given":"Pi-Shan","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9]]},"reference":[{"key":"e_1_3_3_2_2","article-title":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019","volume":"7","author":"GBD 2019 Dementia Forecasting Collaborators","year":"2022","unstructured":"GBD 2019 Dementia Forecasting Collaborators. 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