{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T12:24:28Z","timestamp":1778070268096,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Alzheimer's and Related Diseases Research Award Fund","award":["23-3"],"award-info":[{"award-number":["23-3"]}]},{"DOI":"10.13039\/100013759","name":"Commonwealth Health Research Board","doi-asserted-by":"publisher","award":["274-08-17"],"award-info":[{"award-number":["274-08-17"]}],"id":[{"id":"10.13039\/100013759","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In the past decade, Alzheimer's disease (AD) researchers have found that the formation of amyloid aggregates occurs after dysregulation of respiratory chain activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Using our developing mathematical model to identify potential therapeutic targets for AD treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We have constructed a mathematical model for AD that incorporates enzyme activities and kinetics, and protein and mRNA expression levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our analyses of gene expression in AD brains provide complimentary evidence that changes in mitochondrial energy production and biogenesis accompany AD pathogenesis. Using this data, we created a mitochondrial model of electron transport chain supercomplex assembly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      By carrying out sensitivity analyses of responses to oxidative stress and effects of gene expression on energy production, we demonstrate how oxidative stress and energy deficits change the initial antioxidant defense system and impact the progression of AD. We investigated the impact of gene expression changes in 9 genes as new therapeutic options via metabolic flux analysis of supercomplex assembly. Through careful analysis, we propose that UQCRC1 may be an effective therapy option for\n                      <jats:italic>in vitro<\/jats:italic>\n                      AD treatment testing.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251362889","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T06:44:17Z","timestamp":1755153857000},"page":"734-742","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Integrating mitochondrial gene expression data to model the effects of respirasome supercomplex formation on reactive oxygen species production in Alzheimer's disease models"],"prefix":"10.1177","volume":"107","author":[{"given":"Morgan","family":"Shelton","sequence":"first","affiliation":[{"name":"Department of Chemistry, The College of William and Mary, Williamsburg, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6996-9699","authenticated-orcid":false,"given":"Kimberly A","family":"Kerns","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Translational Sciences, Macon and Joan Brock Virginia Health Sciences Eastern Virginia Medical School at Old Dominion University, Norfolk, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonali","family":"Shirali","sequence":"additional","affiliation":[{"name":"Department of Chemistry, The College of William and Mary, Williamsburg, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7638-9786","authenticated-orcid":false,"given":"Frank J","family":"Castora","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Translational Sciences, Macon and Joan Brock Virginia Health Sciences Eastern Virginia Medical School at Old Dominion University, Norfolk, VA, USA"},{"name":"Department of Neurology, Macon and Joan Brock Virginia Health Sciences Eastern Virginia Medical School at Old Dominion University, Norfolk, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randolph A","family":"Coleman","sequence":"additional","affiliation":[{"name":"Department of Chemistry, The College of William and Mary, Williamsburg, VA, 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