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In AD-MCI group, superotemporal NFLT maintained a positive correlation with memory score; the NFLTs in superior and nasoupper quadrants were negatively associated with GCA score. In AD-D group, superonasal NFLT was negatively correlated with matrix metalloproteinase 9 level in cerebrospinal fluid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In AD patients, thinner peripapillary NFLT mirrors worse memory, significant BBB damage, the atrophy of medial temporal lobe and cortex. In AD-MCI patients, thinner NFLT mirrors worse memory and cortical atrophy. In AD-D patients, thinner NFLT mirrors significant BBB damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251364736","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T07:14:26Z","timestamp":1754637266000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlations of retinal morphology with clinical symptoms, blood-brain barrier, and brain structure in patients with Alzheimer's disease"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3609-8471","authenticated-orcid":false,"given":"Jing","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 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