{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:35:32Z","timestamp":1777397732709,"version":"3.51.4"},"reference-count":135,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Preclinical risk for Alzheimer's disease (AD), including amyloid-\u03b2 (A\u03b2) deposition, begins 10\u201315 years prior to diagnosis. In addition to genetics, hypertension, type 2 diabetes, and depression in midlife are major risk factors for AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Here, we assessed sex differences in associations of AD risk status with memory circuitry function and AD pathology in midlife.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      High- (HR) and low-risk (LR) participants (N\u2009=\u200999; ages 52\u201371 years) were recruited from the Mass General Brigham Biobank. HR participants have genetic risk (\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      ) plus hypertension, type 2 diabetes, and\/or depression; LR participants have no genetic or clinical risk. Participants underwent neuropsychological assessments of verbal, associative, and working memory, functional MRI (fMRI) scans while completing a working memory and verbal encoding task, and PET imaging scans. A\u03b2 deposition was detected using PET C-11PiB and calculated as distribution volume ratio.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HR status was significantly associated with lower scores in associative memory, altered fMRI BOLD activity in memory circuitry regions, and higher A\u03b2 deposition, primarily in women. Further, altered task-based fMRI activity was related to worse memory performance and higher A\u03b2 accumulation in women. While some effects were observed in men, effect sizes were smaller and did not survive correction for multiple comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Results demonstrated that genetic and clinical risk factors can help identify in a sex-dependent manner those in midlife who are at increased risk of developing AD to target for early intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251366701","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T05:37:29Z","timestamp":1755495449000},"page":"1450-1468","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Sex differences in the impact of genetic and clinical risk factors for Alzheimer's disease in midlife"],"prefix":"10.1177","volume":"107","author":[{"given":"Kyoko","family":"Konishi","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Innovation Center on Sex Differences in Medicine, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dylan S","family":"Spets","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Innovation Center on Sex Differences in Medicine, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paris","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Aroner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Innovation Center on Sex Differences in Medicine, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah M","family":"Sant","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Innovation Center on Sex Differences in Medicine, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry","family":"Prokopenko","sequence":"additional","affiliation":[{"name":"Innovation Center on Sex Differences in Medicine, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hrishikesh","family":"Lokhande","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harlyn","family":"Aizley","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Innovation Center on Sex Differences in Medicine, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brianna","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Remington","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Innovation Center on Sex Differences in Medicine, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Spooner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Innovation Center on Sex Differences in Medicine, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Touroutoglou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Rosand","sequence":"additional","affiliation":[{"name":"Innovation Center on Sex Differences in Medicine, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Arnold","sequence":"additional","affiliation":[{"name":"Innovation Center on Sex Differences in Medicine, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Lee","sequence":"additional","affiliation":[{"name":"Biostatistics Center, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Department of Medicine, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradford","family":"Dickerson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolph E","family":"Tanzi","sequence":"additional","affiliation":[{"name":"Innovation Center on Sex Differences in Medicine, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanuja","family":"Chitnis","sequence":"additional","affiliation":[{"name":"Innovation Center on Sex Differences in Medicine, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1689-7791","authenticated-orcid":false,"given":"Jill M","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Innovation Center on Sex Differences in Medicine, Massachusetts General Hospital, Boston, MA, USA"},{"name":"Department of Medicine, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.03.001"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.03.005"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00275"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-017-0069-5"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2020.1944"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550160069041"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.04.007"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3579-13.2014"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190035"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr255"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2016.05.013"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101133"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2011.11.018"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.5.530"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70072-2"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2004.09.005"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1497-2"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.2174\/15672050113109990006"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000013174"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.04.008"},{"key":"e_1_3_3_22_2","first-page":"600","article-title":"Risk factors for \u03b2-amyloid deposition in healthy aging: vascular and genetic effects","volume":"70","author":"Rodrigue KM","year":"2013","unstructured":"Rodrigue KM, Rieck JR, Kennedy KM, et al. Risk factors for \u03b2-amyloid deposition in healthy aging: vascular and genetic effects. J Am Med Assoc 2013; 70: 600\u2013606.","journal-title":"J Am Med Assoc"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00085"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000125859.71051.83"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlw047"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.685"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.03.079"},{"key":"e_1_3_3_28_2","first-page":"2857","article-title":"Reorganization of functional networks in verbal working memory circuitry in early midlife: the impact of sex and menopausal status","volume":"27","author":"Jacobs EG","year":"2017","unstructured":"Jacobs EG, Weiss B, Makris N, et al. Reorganization of functional networks in verbal working memory circuitry in early midlife: the impact of sex and menopausal status. Cereb Cortex 2017; 27: 2857\u20132870.","journal-title":"Cereb Cortex"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0951-16.2016"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24441"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.02.069"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0926-6410(96)00058-4"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2004.07.009"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0032-9"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05529.x"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960909)373:1<108::AID-CNE9>3.0.CO;2-8"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0498-447"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004425"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1934"},{"key":"e_1_3_3_40_2","first-page":"133","volume-title":"Administration and scoring manual","author":"Wechsler D","year":"1997","unstructured":"Wechsler D. WAIS-III, Wechsler Adult Intelligence Scale. In: Administration and scoring manual. 3rd ed. New York: The Psychological Corporation, 1997, pp.133\u2013135.","edition":"3"},{"key":"e_1_3_3_41_2","volume-title":"National Adult Reading Test (NART): Test Manual","author":"Nelson HE","year":"1982","unstructured":"Nelson HE. National Adult Reading Test (NART): Test Manual. Windsor, England: NFER-Nelson, 1982."},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1080\/13854046.2014.911351"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2011.06.006"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1080\/01688638908400920"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1080\/01688638408401233"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.4.827"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-091150"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.7.1119"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1080\/01688638708405055"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1995.1023"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195092509.001.0001"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.9.1841"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.12.008"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.1992.4.4.352"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac245"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202753"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202753"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-018-0459-7"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.2188"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24135"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0305-12.2012"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5185"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054713"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-016-9523-8"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3601"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.04.010"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2015.07.001"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000401"},{"key":"e_1_3_3_70_2","first-page":"52","article-title":"Oestrogens and the structural and functional plasticity of neurons: implications for memory, ageing, and neurodegenerative processes","volume":"191","author":"McEwen BS","year":"1995","unstructured":"McEwen BS, Gould E, Orchinik M, et al. Oestrogens and the structural and functional plasticity of neurons: implications for memory, ageing, and neurodegenerative processes. Ciba Found Symp 1995; 191: 52\u201366. discussion 66\u201373.","journal-title":"Ciba Found Symp"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960909)373:1<108::AID-CNE9>3.0.CO;2-8"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199709290-00004"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.1997.1433"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.1998.1473"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2004.07.006"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.116.3.411"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.09.014"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2016.05.008"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20468"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(01)00083-X"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.06.012"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep32833"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(198805)44:3<403::AID-JCLP2270440315>3.0.CO;2-0"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23973"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000771"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.04.011"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22218"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1808"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185926"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2015.05.009"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3369-06.2006"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(99)00025-6"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.203"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2004.09.005"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb23050.x"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31363-6"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.3090"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70072-2"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.5.530"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2015-1137"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.968792"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12991-023-00486-7"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00247"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(93)90026-G"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171100016X"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.4.385"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.12.084"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1550-8579(05)80054-3"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2008.02648.x"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3260-6"},{"key":"e_1_3_3_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60040-4"},{"key":"e_1_3_3_112_2","first-page":"600","article-title":"Risk factors for \u03b2-amyloid deposition in healthy aging: vascular and genetic effects","volume":"70","author":"Rodrigue KM","year":"2013","unstructured":"Rodrigue KM, Rieck JR, Kennedy KM, et al. Risk factors for \u03b2-amyloid deposition in healthy aging: vascular and genetic effects. J Am Med Assoc 2013; 70: 600\u2013606.","journal-title":"J Am Med Assoc"},{"key":"e_1_3_3_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2008.12.001"},{"key":"e_1_3_3_114_2","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e3180f63373"},{"key":"e_1_3_3_115_2","doi-asserted-by":"publisher","DOI":"10.1159\/000356540"},{"key":"e_1_3_3_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.10.007"},{"key":"e_1_3_3_117_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.186.3.197"},{"key":"e_1_3_3_118_2","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2007.9.1\/ammoeller"},{"key":"e_1_3_3_119_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.8.876"},{"key":"e_1_3_3_120_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.0098"},{"key":"e_1_3_3_121_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.1.49"},{"key":"e_1_3_3_122_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-130698"},{"key":"e_1_3_3_123_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182190d09"},{"key":"e_1_3_3_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00035-7"},{"key":"e_1_3_3_125_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.11.1809"},{"key":"e_1_3_3_126_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.72"},{"key":"e_1_3_3_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.04.009"},{"key":"e_1_3_3_128_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291716000209"},{"key":"e_1_3_3_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.12.014"},{"key":"e_1_3_3_130_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4943(96)00761-3"},{"key":"e_1_3_3_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2019.146303"},{"key":"e_1_3_3_132_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617703910113"},{"key":"e_1_3_3_133_2","doi-asserted-by":"publisher","DOI":"10.1080\/01688638908400912"},{"key":"e_1_3_3_134_2","doi-asserted-by":"publisher","DOI":"10.1080\/138255890969483"},{"key":"e_1_3_3_135_2","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.11.4.577"},{"key":"e_1_3_3_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.04.008"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251366701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877251366701","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251366701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:11:36Z","timestamp":1777371096000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877251366701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,17]]},"references-count":135,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/13872877251366701"],"URL":"https:\/\/doi.org\/10.1177\/13872877251366701","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,17]]}}}