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The Visual Cognitive Assessment Test (VCAT), a language-neutral visual-based tool, effectively identifies MCI, but its correlation with A\u03b2 pathology remains unverified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the ability of VCAT to distinguish between amyloid-positive (A\u03b2+) and amyloid-negative (A\u03b2\u2212) people with different cognitive status and compare its performance with the Montreal Cognitive Assessment (MoCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this cross-sectional analysis conducted at the First Affiliated Hospital of Sun Yat-sen University, 139 cognitively normal (CN) individuals and 231 patients with MCI were enrolled. Participants underwent baseline data registration, VCAT, Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination, Clinical Dementia Rating, amyloid PET assessments, and MRI scans. The main outcome measures considered the ability of the VCAT to distinguish between amyloid-positive and amyloid-negative MCI patients, as indicated by the area under the curve (AUC) values\n                      <jats:bold>.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>VCAT and MoCA showed comparable efficacy in differentiating MCI from CN. For A\u03b2 deposition discrimination, VCAT showed numerically higher accuracy than MoCA for detecting A\u03b2+ MCI (AUC 0.830 versus 0.797; sensitivity 72.7% versus 66.7%). VCAT's discriminative ability relied on memory and executive function domains. Shortened VCAT versions demonstrated reduced efficacy compared to the full VCAT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>VCAT correlates well with PET-detected A\u03b2 deposition and shows marginally superior performance to MoCA in identifying A\u03b2+ MCI. However, abbreviated VCAT versions are less effective for A\u03b2 detection in MCI, highlighting the need for full-test administration in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251371718","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T11:48:48Z","timestamp":1756727328000},"page":"1498-1510","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Visual Cognitive Assessment Test correlates with brain amyloid status in Alzheimer's disease-related mild cognitive impairment"],"prefix":"10.1177","volume":"107","author":[{"given":"Feng-juan","family":"Su","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University; Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-cheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University; Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-chong","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi Jin","family":"Leow","sequence":"additional","affiliation":[{"name":"Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore"},{"name":"Neuroscience and Mental Health Programme, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pricilia","family":"Tanoto","sequence":"additional","affiliation":[{"name":"Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore"},{"name":"Neuroscience and Mental Health Programme, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5962-0712","authenticated-orcid":false,"given":"Li-shan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University; Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-neng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University; Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Yi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University; Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6973-1520","authenticated-orcid":false,"given":"Hai-fan","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University; 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