{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:48:10Z","timestamp":1789678090781,"version":"4.0.1"},"reference-count":39,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS017950"],"award-info":[{"award-number":["NS017950"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["UH2 NS100605"],"award-info":[{"award-number":["UH2 NS100605"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Research Board of Ireland","award":["CSF-2020-011"],"award-info":[{"award-number":["CSF-2020-011"]}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG033193"],"award-info":[{"award-number":["R01 AG033193"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG049607"],"award-info":[{"award-number":["R01 AG049607"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG054076"],"award-info":[{"award-number":["R01 AG054076"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG049505"],"award-info":[{"award-number":["U01 AG049505"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG052409"],"award-info":[{"award-number":["U01 AG052409"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["75N92019D00031"],"award-info":[{"award-number":["75N92019D00031"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201500001"],"award-info":[{"award-number":["HHSN268201500001"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-25195"],"award-info":[{"award-number":["N01-HC-25195"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL60040"],"award-info":[{"award-number":["R01 HL60040"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL70100"],"award-info":[{"award-number":["R01 HL70100"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002081","name":"Irish Research Council","doi-asserted-by":"publisher","award":["GOIPG\/2023\/5216"],"award-info":[{"award-number":["GOIPG\/2023\/5216"]}],"id":[{"id":"10.13039\/501100002081","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The relationship between blood pressure (BP) trajectories across early (\u223c40 years) into mid-life (\u223c55 years) and preclinical dementia has not previously been well studied using positron emission tomography (PET) imaging outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the association between BP trajectories across early mid-life into mid mid-life and amyloid- and tau-PET burden in adults without clinical dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective cohort study included dementia-free Framingham Heart Study 3\n                      <jats:sup>rd<\/jats:sup>\n                      generation participants with data on remote BP (2002\u20132005) and recent BP (2016\u20132019) who participated in\n                      <jats:sup>11<\/jats:sup>\n                      C-Pittsburgh Compound-B (PiB)-PET and\/or\n                      <jats:sup>18<\/jats:sup>\n                      F-Flortaucipir (FTP)-PET scans between 2016 to 2022. Outcomes included global amyloid deposition (in the frontal, lateral temporal, parietal and retrosplenial cortices, FLR region) and entorhinal tau deposition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 410 participants (mean age 40\u2009\u00b1\u20098 years at remote exam, 56\u2009\u00b1\u20098 years recent exam), the mean time between the remote exam BP measurement and PET was 16\u2009\u00b1\u20092 years. A steep change (slope of \u22650.5 or \u2264\u22120.5\u2005mmHg\/year) in DBP over early to mid-life was associated with increased entorhinal tau-PET deposition (\u03b2\u2009=\u20090.02; 95% CI\u2009=\u20090.01, 0.04; p\u2009=\u20090.047), driven by a steep decline in DBP (\u03b2\u2009=\u20090.04; 95% CI\u2009=\u20090.01, 0.07; p\u2009\n                      <jats:italic toggle=\"yes\">=<\/jats:italic>\n                      \u20090.01). Persistent hypertension, new-onset hypertension, resolved hypertension or a steep change in SBP were not associated with amyloid or tau burden.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In adults without clinical dementia, a steep DBP decline from early mid-life into mid-life was associated with tau deposition in the entorhinal cortex, one of the earliest affected regions in Alzheimer's disease. Maintaining normotension across the \u223c15\u201316 years mid-life period may reduce the future risk of tau-PET burden in the brain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251372561","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T13:31:20Z","timestamp":1756906280000},"page":"1674-1681","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["A steep decline in diastolic blood pressure over early to mid-life is associated with tau-PET burden in dementia-free adults"],"prefix":"10.1177","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2042-257X","authenticated-orcid":false,"given":"Martin","family":"Mulligan","sequence":"first","affiliation":[{"name":"School of Medicine, University of Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8551-7778","authenticated-orcid":false,"given":"Alexa S","family":"Beiser","sequence":"additional","affiliation":[{"name":"The Framingham Heart Study, Framingham, MA, USA"},{"name":"Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA"},{"name":"Department of Neurology, Boston University Chobanian &amp; Avedisian School of Medicine, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"O\u2019Donnell","sequence":"additional","affiliation":[{"name":"The Framingham Heart Study, Framingham, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6779-5106","authenticated-orcid":false,"given":"Ayantika","family":"Banerjee","sequence":"additional","affiliation":[{"name":"The Framingham Heart Study, Framingham, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saptaparni","family":"Ghosh","sequence":"additional","affiliation":[{"name":"The Framingham Heart Study, Framingham, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Thibault","sequence":"additional","affiliation":[{"name":"Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"El Fakhri","sequence":"additional","affiliation":[{"name":"Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A","family":"Johnson","sequence":"additional","affiliation":[{"name":"Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha","family":"Seshadri","sequence":"additional","affiliation":[{"name":"The Framingham Heart Study, Framingham, MA, USA"},{"name":"Department of Neurology, Boston University Chobanian &amp; Avedisian School of Medicine, Boston, MA, USA"},{"name":"Glenn Biggs Institute for Alzheimer's &amp; Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, \rTX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3589-2964","authenticated-orcid":false,"given":"Emer R","family":"McGrath","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Galway, Galway, Ireland"},{"name":"The Framingham Heart Study, Framingham, MA, USA"},{"name":"HRB Clinical Research Facility, University of Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"e_1_3_3_2_2","article-title":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019","volume":"7","author":"GBD 2019 Dementia Forecasting Collaborators","year":"2022","unstructured":"GBD 2019 Dementia Forecasting Collaborators. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019. Lancet Public Health 2022; 7: e105\u2013e125.","journal-title":"Lancet Public Health"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01296-0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.19672"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(19)30074-9"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004741"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2174\/1567202616666181128114523"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.14993"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000133128.42462.ef"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.033697"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14310"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17788"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17797"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.06.020"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-01149-7"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.08.008"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30228-5"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.3090"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.0244"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.18479"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-7435(75)90037-7"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22333"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn016"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.123"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.04.011"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24546"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284427"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.06.011"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12377"},{"key":"e_1_3_3_32_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0197-4580(00)00106-8","article-title":"Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS","volume":"21","author":"Petrovitch H","year":"2000","unstructured":"Petrovitch H, White LR, Izmirilian G, et al. Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS. Neurobiol Aging 2000; 21: 57\u201362.","journal-title":"Neurobiol Aging"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005951"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2005.036053"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-014-0127-9"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X221141139"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001991"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004887"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.11.2108"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210191"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251372561","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877251372561","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251372561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:11:40Z","timestamp":1777371100000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877251372561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,3]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/13872877251372561"],"URL":"https:\/\/doi.org\/10.1177\/13872877251372561","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,3]]}}}