{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:36:04Z","timestamp":1793813764531,"version":"4.6.1"},"reference-count":80,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Enlarged perivascular spaces (EPVS) and mild behavioral impairment (MBI) are associated with greater dementia risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We investigated cross-sectional associations between EPVS burden and MBI presence and symptom severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were dementia-free older adults in the Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) study. EPVS were assessed using a validated visual rating scale applied to T2-weighted magnetic resonance imaging. MBI was measured using the informant-reported MBI Checklist (MBI-C) with a cut-point of &gt;5 for MBI presence. Multivariable logistic and zero-inflated negative binomial regressions modelled EPVS associations with MBI presence and symptom severity, respectively, adjusting for age, education, Montreal Cognitive Assessment score, and presence of hypertension with an EPVS*sex interaction term.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 363 participants (52.9% female), every 1-point rise in total EPVS score was associated with 1.28-fold greater odds of having MBI (95%CI:1.06\u20131.53, p\u2009=\u20090.009). When examining regional EPVS burden, those with higher centrum semiovale scores had greater odds of MBI (aOR\u2009=\u20091.47, 95%CI:1.08\u20132.00, p\u2009=\u20090.01), but this association was not significant for the basal ganglia (aOR\u2009=\u20091.37, 95%CI:0.95\u20131.97, p\u2009=\u20090.09) or midbrain (aOR\u2009=\u20091.49, 95%CI:0.80\u20132.79, p\u2009=\u20090.21). Total and regional EPVS scores were not associated with MBI symptom severity. None of the associations were moderated by sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Older adults with greater global and centrum semiovale EPVS burden are more likely to have MBI. These findings suggest that early microvascular pathology may contribute to later-life emergent and persistent behavioral symptoms, although longitudinal data are required, along with other indicators of vascular pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251372566","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T15:32:18Z","timestamp":1757691138000},"page":"1682-1692","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The cross-sectional associations between enlarged perivascular spaces and mild behavioral impairment in dementia-free older adults"],"prefix":"10.1177","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7691-5703","authenticated-orcid":false,"given":"Dinithi","family":"Mudalige","sequence":"first","affiliation":[{"name":"Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada"},{"name":"Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan X","family":"Guan","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham A","family":"McLeod","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric E","family":"Smith","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada"},{"name":"Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada"},{"name":"Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravind","family":"Ganesh","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada"},{"name":"Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada"},{"name":"Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada"},{"name":"O\u2019Brien Institute for Public Health, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5529-3731","authenticated-orcid":false,"given":"Zahinoor","family":"Ismail","sequence":"additional","affiliation":[{"name":"Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada"},{"name":"Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada"},{"name":"Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada"},{"name":"O\u2019Brien Institute for Public Health, University of Calgary, Calgary, AB, Canada"},{"name":"Department of Psychiatry, University of Calgary, Calgary, AB, Canada"},{"name":"Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK"},{"name":"Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4245"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25246"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25380"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1717-7"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/131216"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.1017"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.5414\/NP300418"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.598326"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002480"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.04.022"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00131-X"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70124-8"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493019830321"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.3122"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190527"},{"key":"e_1_3_3_17_2","article-title":"MRI-visible perivascular spaces and risk of incident dementia","volume":"99","author":"Jose RR","year":"2022","unstructured":"Jose RR, Adlin P, Hugo JA, et al. 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