{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:23:22Z","timestamp":1792589002499,"version":"4.5.0"},"reference-count":63,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100010969","name":"Alzheimer Nederland","doi-asserted-by":"publisher","award":["WE.03-2023-21cb"],"award-info":[{"award-number":["WE.03-2023-21cb"]}],"id":[{"id":"10.13039\/501100010969","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071294"],"award-info":[{"award-number":["82071294"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["202007030010"],"award-info":[{"award-number":["202007030010"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["No 202106380078"],"award-info":[{"award-number":["No 202106380078"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Disruptions of deep medullary veins (DMV) have been associated with the radiological severity and cognitive impairment observed in cerebral small vessel disease (SVD). Glymphatic dysfunction may serve as a potential mechanism underlying these associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to clarify the associations between DMV disruptions, MRI indices previously hypothesized as related to glymphatic function, white matter hyperintensities (WMH), and cognitive impairment in SVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study included 133 SVD participants. DMV disruptions were visually rated on susceptibility-weighted imaging (SWI). Five MRI indices related to glymphatic function were measured: the diffusion tensor imaging along the perivascular space (DTI-ALPS), free water (FW) fraction, choroid plexus (Cp) volumes, perivascular spaces in basal ganglia (BG-PVS) and white matter (WM-PVS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher DMV scores were associated with higher WMH volumes (\u03b2\u2009=\u20090.55, p\u2009&lt;\u20090.001) and lower Montreal Cognitive Assessment (MoCA) scores (\u03b2\u2009=\u2009\u22120.24, p\u2009=\u20090.003). Higher DMV scores were correlated with lower DTI-ALPS values, higher FW fraction, higher volumes in Cp, BG-PVS, and WM-PVS (all p\u2009&lt;\u20090.001). DTI-ALPS values and BG-PVS volumes mediated the associations between DMV scores and WMH volumes, with only BG-PVS volumes mediating the associations between DMV scores and MoCA scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggested that DMV disruptions contribute to WMH burden and cognitive impairment in SVD. This effect could be mediated by MRI markers indicative of glymphatic dysfunction, particularly the enlargement of BG-PVS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251372926","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T13:32:55Z","timestamp":1756906375000},"page":"1780-1792","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Disruptions of deep medullary veins and MRI indices of glymphatic function in cerebral small vessel disease"],"prefix":"10.1177","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5570-2657","authenticated-orcid":false,"given":"Mengshi","family":"Liao","sequence":"first","affiliation":[{"name":"Sun Yat-sen University"},{"name":"Department of Neurology, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, 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