{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:36:48Z","timestamp":1777397808762,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous studies reported an inverse association of cancer with dementia risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To study associations of cancer diagnoses with risk of a dementia diagnosis in a large case-control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included patients with a dementia diagnosis and controls matched 1:2 for age, sex, region, and earliest year of outpatient treatment in a case-control study from health insurance claims of outpatient consultations. Exposure included seventeen cancer categories. We compared the annual prevalence trajectories of cancer categories between dementia cases and controls over a period of 10 years before the index date. We report unadjusted odds ratios (ORs) and ORs adjusted for established dementia risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 1,686,759 patients with incident dementia and 3,373,518 matched controls. We identified four types of associations: Cancers with equal or lower prevalence in controls at year \u221210 and higher prevalence in controls after year 6 to 4 before the index date; with higher prevalence in controls at all time points; with a lower prevalence in controls up to three years before the index date and higher prevalence after that; and with equal prevalence in cases and controls until year \u22129 and a steep increase in controls after that. When using adjusted ORs the overall pattern of an inverse association of cancer with dementia was maintained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data suggest that a mixture of causes contributes to the inverse association of cancer and dementia diagnoses, including selective survival, underdiagnosis of dementia after cancer and of cancer in dementia, but also shared biological factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251374675","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T18:31:23Z","timestamp":1758825083000},"page":"98-106","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Inverse association of cancer with diagnoses of dementia in a large health claims case-control study"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3586-3194","authenticated-orcid":false,"given":"Stefan","family":"Teipel","sequence":"first","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany"},{"name":"Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manas","family":"Akmatov","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Healthcare Atlas, Central Research Institute of Ambulatory Health Care in Germany, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3425-0089","authenticated-orcid":false,"given":"Bernhard","family":"Michalowsky","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Greifswald, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4321-6090","authenticated-orcid":false,"given":"Steffi","family":"Riedel-Heller","sequence":"additional","affiliation":[{"name":"Institute of Social Medicine, Occupational Health and Public Health, Faculty of Medicine, University of Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4707-777X","authenticated-orcid":false,"given":"Christian","family":"Junghanss","sequence":"additional","affiliation":[{"name":"Clinic for Hematology, Oncology and Palliative Care, Department of Internal Medicine, Rostock University Medical Center, Rostock, Germany"},{"name":"Comprehensive Cancer Center Mecklenburg-Vorpommern (CCC-MV), Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1337-6640","authenticated-orcid":false,"given":"Jakob","family":"Holstiege","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Healthcare Atlas, Central Research Institute of Ambulatory Health Care in Germany, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Bohlken","sequence":"additional","affiliation":[{"name":"Institute of Social Medicine, Occupational Health and Public Health, Faculty of Medicine, University of Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179857"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-01090-9"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13019"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.25515"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000356498"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells11121930"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-023-02470-0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000200173"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2022.272"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.11.002"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01296-0"},{"key":"e_1_3_2_15_2","volume-title":"Statistics with confidence: Confidence intervals and statistical guidelines","author":"Altman DG","year":"2000","unstructured":"Altman DG, Machin D, Bryant TN, et al. 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