{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:58:46Z","timestamp":1785304726674,"version":"3.55.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                    Odds ratios (OR) can overestimate risk when the prevalence of outcomes is more than 10%. We compared logistic and modified Poisson models in 5843 National Alzheimer's Coordinating Center decedents to examine associations of apolipoprotein (\n                    <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                    ) \u03b54, age at death, sex, and education with 7 neuropathologies. OR for neuritic plaques (6.28) and Braak stage (4.90) attenuated to prevalence rate ratios of 1.38 and 1.08; similar attenuation occurred for Lewy body disease, arteriolosclerosis, cerebral amyloid angiopathy, and infarcts. Modified Poisson regression is critical for valid risk estimation, reliable interpretations, and accurate risk stratification in non-rare outcome studies.\n                  <\/jats:p>","DOI":"10.1177\/13872877251375099","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T16:41:56Z","timestamp":1757436116000},"page":"53-59","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Application of modified Poisson regression for risk estimation of major neuropathology outcomes: National Alzheimer's coordinating center"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6259-9456","authenticated-orcid":false,"given":"Cellas A","family":"Hayes","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Population Health, Stanford University School of Medicine, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle C","family":"Odden","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health, Stanford University School of Medicine, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Roland J","family":"Thorpe","sequence":"additional","affiliation":[{"name":"Program for Research on Men's Health, Johns Hopkins Center for Health Disparities Solutions, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA"},{"name":"Johns Hopkins Alzheimer's Disease Resource Center for Minority Aging Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002175"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww224"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24388"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws234"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.19.1690"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwaa044"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh090"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12939"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-021-01260-0"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlz126"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-025-02012-0"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.10.007"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0910-3"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201187"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874297101205010013"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg074"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/geroni\/igaa047"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.08.007"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006212"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251375099","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877251375099","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251375099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:11:46Z","timestamp":1777371106000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877251375099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,9]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1177\/13872877251375099"],"URL":"https:\/\/doi.org\/10.1177\/13872877251375099","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,9]]}}}