{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:44:47Z","timestamp":1792799087183,"version":"4.5.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>As plasma biomarkers like p-tau217 move towards clinical use in Alzheimer's disease (AD), it is important to understand how kidney function may influence their accuracy. Even mild chronic kidney disease (CKD) can alter biomarker levels, potentially impacting test performance. While accounting for renal function may improve specificity, it could reduce sensitivity without greatly changing overall diagnostic accuracy. Most studies focus on mild CKD, leaving gaps in understanding severe CKD\u2014especially in real-world settings like primary care. Including renal indices such as eGFR in diagnostic models could help improve interpretation and minimize misclassification in older adults, where CKD is common.<\/jats:p>","DOI":"10.1177\/13872877251375101","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T16:42:36Z","timestamp":1757436156000},"page":"75-78","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Integrating kidney function assessment into the clinical interpretation of plasma Alzheimer's disease biomarkers"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7229-3226","authenticated-orcid":false,"given":"Burak","family":"Arslan","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience &amp; Physiology, the Sahlgrenska Academy at the University of Gothenburg, M\u00f6lndal, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience &amp; Physiology, the Sahlgrenska Academy at the University of Gothenburg, M\u00f6lndal, Sweden"},{"name":"Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA"},{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden"},{"name":"Department of Neurodegenerative Disease, Institute of Neurology, University College London, London, UK"},{"name":"UK Dementia Research Institute, University College London, London, UK"},{"name":"Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China"},{"name":"Centre for Brain Research, Indian Institute of Science, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J","family":"Ashton","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience &amp; Physiology, the Sahlgrenska Academy at the University of Gothenburg, M\u00f6lndal, Sweden"},{"name":"Banner Alzheimer's Institute and University of Arizona, Phoenix, AZ, USA"},{"name":"Banner Sun Health Research Institute, Sun City, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-025-04130-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-025-01692-z"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12787"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.0199"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12466"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01822-2"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000210287"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.01.019"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251350718"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kisu.2021.11.003"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2024.100897"},{"key":"e_1_3_3_13_2","article-title":"Changes in Alzheimer's disease blood biomarkers in kidney failure before and after kidney transplant","volume":"16","author":"Blankenship AE","year":"2024","unstructured":"Blankenship AE, Yoksh L, Kueck PJ, et al. 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