{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:37:42Z","timestamp":1777397862490,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100006636","name":"Forskningsr\u00e5det om H\u00e4lsa, Arbetsliv och V\u00e4lf\u00e4rd","doi-asserted-by":"publisher","award":["2021-01799"],"award-info":[{"award-number":["2021-01799"]}],"id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Studies have shown significant heterogeneity in the longitudinal progression of dementias, including Alzheimer's disease. Growth mixture models have detected up to 4 classes that differ in both baseline Mini-Mental State Exam (MMSE) and rate of decline over time. Most analyses focus on adults over age 65 and investigate group differences in demographic and health variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The current analysis focused on adults with young onset dementia (YOD) and examined the role of demographic and support variables in differentiating latent classes of longitudinal progression of cognitive status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sample included 1025 adults (55% women) registered in the Swedish Dementia Register prior to age 65 with at least 3 registrations. Age at baseline was 38 to 64 (mean\u2009=\u200959.3, SD\u2009=\u20094.1); follow-up duration ranged from 1 to 12 years (mean\u2009=\u20094.6, SD\u2009=\u20092.0).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Growth mixture models identified 5 classes: high baseline MMSE and moderate decline over time (48.5%), intermediate baseline MMSE and moderate decline (34.5%), high baseline MMSE and steep decline (13.4%), low baseline and generally stable MMSE over time (2.6%), and high baseline with precipitous decline (1.0%). Latent classes differed in age at diagnosis, diagnostic categories, number of medications, and having home help services.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Results highlight that YOD is just as heterogeneous as later onset dementia; therefore, it is vital that people with YOD get early diagnosis and a case manager to help identity and meet their individual needs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251376040","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T16:38:15Z","timestamp":1757608695000},"page":"262-272","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Latent classes and progression of Mini-Mental State Examination scores in young-onset dementia: Data from the Swedish Dementia 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