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These changes can be subtle and fluctuating, and thus easily missed during intermittent clinic visits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the relationship of changes in self-perceived internal states and needs to the development of cognitive impairment over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Weekly online reports of health-related activities and mood in relation to MCI were assessed for up to 2.9 years in older adults participating in the Oregon Life Laboratory, a study using home-based unobtrusive remote sensing of physical, cognitive, behavioral, physiological, and health-related activities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The analytic sample included 129 cognitively healthy volunteers followed for a mean of 2.9\u2009\u00b1\u20091.2 years. Mean age was 83.5\u2009\u00b1\u20097.8 years, mean education was 15.7\u2009\u00b1\u20092.7 years, and 76% were female. Twenty-two participants (17%) developed MCI or dementia while 107 remained cognitively healthy. Over time, more of the participants destined to develop MCI reported: (1) loneliness (p\u2009=\u20090.049), (2) low mood (p\u2009=\u20090.08), (3) pain intensity (p\u2009=\u20090.03) and pain interference (p\u2009=\u20090.01), and (4) needing in-home assistance (p\u2009=\u20090.02) than those remaining cognitively healthy. Baseline scores assessing these symptoms were not clinically concerning, predictive of MCI, nor significantly different between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Longitudinal home-based online assessment of non-cognitive aspects of function or internal states (loneliness, mood, pain, needing more assistance) can be sensitive early indicators of changes in brain function leading to MCI and ADRD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251376524","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T04:49:02Z","timestamp":1758602942000},"page":"312-323","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal online weekly reports of non-cognitive symptoms and events can differentiate incident mild cognitive impairment from stable cognitively healthy older adults"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8017-3483","authenticated-orcid":false,"given":"Christine","family":"McClure","sequence":"first","affiliation":[{"name":"Oregon Health &amp; 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