{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:12:57Z","timestamp":1787019177901,"version":"build-2736575974"},"reference-count":46,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Japanese Society of Neurology","award":["Overseas Research Program 2023"],"award-info":[{"award-number":["Overseas Research Program 2023"]}]},{"name":"Movement Disorders Society of Japan","award":["Overseas Research Program 2024"],"award-info":[{"award-number":["Overseas Research Program 2024"]}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22dk0207055"],"award-info":[{"award-number":["JP22dk0207055"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100029761","name":"Professional Development and Education Fund","doi-asserted-by":"publisher","award":["Wagner-Torizuka Fellowship 2023-2025"],"award-info":[{"award-number":["Wagner-Torizuka Fellowship 2023-2025"]}],"id":[{"id":"10.13039\/100029761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) is characterized by amyloid-\u03b2 (A\u03b2) and tau protein accumulation, reflected in cerebrospinal fluid (CSF) analysis. However, the interplay among CSF biomarkers, neuroimaging, and cognition remains elusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore associations among neuroimaging features, CSF biomarkers, and cognitive performance in AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty patients with clinically diagnosed AD showing A\u03b2 pathology in CSF underwent neuroimaging assessment of gray matter volume using T1-weighted MRI, cerebral blood flow (CBF) using single-photon emission computed tomography, and white matter hyperintensities (WMHs) using T2-weighted or fluid-attenuated inversion recovery images. Partial least square (PLS) regression identified imaging findings related to CSF biomarkers and Mini-Mental State Examination (MMSE) scores. Structural equation modeling (SEM) explored associations between factors with variable importance in projection (VIP) scores above 1.5 in PLS regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Lateral temporal and occipital gray matter volumes positively correlated with MMSE scores (VIP\u2009=\u20091.95, 1.53), whereas WMHs in parietal and frontal periventricular regions were negatively associated with CSF A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      (VIP\u2009=\u20091.54, 1.58). Lateral temporal CBF was also associated with MMSE scores (VIP\u2009=\u20092.22). SEM analysis showed that reduced CSF A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      was linked to increased WMHs (p\u2009=\u20090.028), which correlated with each region (p\u2009&lt;\u20090.005) and explained the reduced MMSE score (p\u2009=\u20090.013). Lateral temporal CBF correlated with temporo-occipital gray matter volume (p\u2009&lt;\u20090.001) and influenced the MMSE score (p\u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study suggests that amyloid pathology via WMHs and neurodegeneration of the lateral temporal lobe independently contribute to cognitive impairment in patients with AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251376601","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T17:41:41Z","timestamp":1758130901000},"page":"243-252","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Multimodal neuroimaging related to cerebrospinal fluid biomarkers and cognitive function in Alzheimer's disease"],"prefix":"10.1177","volume":"108","author":[{"given":"Yoshihisa","family":"Kitayama","sequence":"first","affiliation":[{"name":"Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3023-3836","authenticated-orcid":false,"given":"Yoshikazu","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoki","family":"Hanayama","sequence":"additional","affiliation":[{"name":"Department of Neurology, Japanese Red Cross Narita Hospital, Narita, 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