{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:12:02Z","timestamp":1787501522899,"version":"build-2736575974"},"reference-count":39,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University","award":["[grant number GA66\/15]"],"award-info":[{"award-number":["[grant number GA66\/15]"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Digits-in-Noise (DIN) test is recognized as a promising hearing screening tool due to its feasibility and reliability, particularly in noisy environments. Although endorsed by the World Health Organization for general population hearing screening, it has not been validated in older adults with cognitive impairment, such as mild cognitive impairment (MCI), and dementia, including Alzheimer's disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To address this gap, this study aimed to evaluate diagnostic accuracy of DIN compared to pure-tone audiometry, marking the first validation of the DIN test in this specific group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants with MCI and dementia were recruited from memory clinics. Each participant underwent an audiologic evaluation, including the Hearing Handicap Inventory for Elderly, pure-tone audiometry, and smartphone-based DIN test. Additionally, the Montreal Cognitive Assessment, was administered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 93 adults (mean age 71.9), an optimal speech reception threshold (SRT) cutoff of \u22123.5 dB yielded 90.5% sensitivity and 50% specificity for detecting moderate hearing loss. The area under the curve was 0.649 for mild hearing loss and 0.746 for moderate. A significant weak positive correlation was observed between SRT and pure tone average (\u03c1= 0.35, p\u2009&lt;\u20090.001)<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings underscore the potential of the DIN test in detecting disabling hearing loss among cognitively impaired individuals, which warrants immediate hearing intervention to improve their quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      Thai Clinical Trials Registry (TCTR20221222004),\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.thaiclinicaltrials.org\/\">https:\/\/www.thaiclinicaltrials.org\/<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251376949","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T16:54:50Z","timestamp":1757696090000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Unveiling the potential of the Digits-in-Noise test as a hearing screening tool for older adults with cognitive impairment"],"prefix":"10.1177","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0676-5891","authenticated-orcid":false,"given":"Patcharaorn","family":"Limkitisupasin","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"},{"name":"School of Otolaryngology, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4205-4184","authenticated-orcid":false,"given":"Pimpanee","family":"Nilchaeng","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7973-8267","authenticated-orcid":false,"given":"Anthipa","family":"Chokesuwattanaskul","sequence":"additional","affiliation":[{"name":"Cognitive Clinical and Computational Neuroscience Excellence Center, Department of Internal Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"},{"name":"Division of Neurology, Department of Internal Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1407-3211","authenticated-orcid":false,"given":"Sookjaroen","family":"Tangwongchai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"},{"name":"Cognitive Impairment and Dementia Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7486-4264","authenticated-orcid":false,"given":"Doris-Eva","family":"Bamiou","sequence":"additional","affiliation":[{"name":"Ear Institute, University College London, London, UK"},{"name":"National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre (Deafness and Hearing Problems Theme), London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6472-7573","authenticated-orcid":false,"given":"Nattawan","family":"Utoomprurkporn","sequence":"additional","affiliation":[{"name":"Otoneurology Unit, Otolaryngology department, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"},{"name":"Hearing Speech and Balance center, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.21.285643"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1996.00550090134019"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01296-0"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.06.020"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.840386"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/geriatrics1020011"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2021.0012"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/14992027.2022.2047234"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.4427"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01406-X"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2025.0192"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/14992027.2018.1550687"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1121\/1.4789933"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/14992027.2021.1902579"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.7874\/jao.2021.00416"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12416"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(97)00006-3"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.7.771"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.7874\/jao.2023.00507"},{"key":"e_1_3_3_22_2","volume-title":"ICD-10: international statistical classification of diseases and related health problems: tenth revision","author":"World Health Organization","year":"2004","unstructured":"World Health Organization. ICD-10: international statistical classification of diseases and related health problems: tenth revision. 2nd ed. Geneva: World Health Organization, 2004.","edition":"2"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.19.230367"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2993"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002864"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3109\/08958378.2014.955932"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000000282"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/audiolres14020030"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq168"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1718700"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare9060769"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-02567-x"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.15009"},{"key":"e_1_3_3_34_2","article-title":"Discrepancy between self-assessed hearing status and measured audiometric evaluation","volume":"12","author":"Kim SY","year":"2017","unstructured":"Kim SY, Kim HJ, Kim MS, et al. Discrepancy between self-assessed hearing status and measured audiometric evaluation. PLoS One 2017; 12: e0182718.","journal-title":"PLoS One"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1177\/1471301219871168"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0b013e3181ac127a"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0000000000000010"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1080\/14992027.2020.1787531"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1177\/23312165231157255"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.2196\/14197"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251376949","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877251376949","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251376949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:11:57Z","timestamp":1777371117000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877251376949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,12]]},"references-count":39,"journal-issue":{"issue":"1_suppl","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1177\/13872877251376949"],"URL":"https:\/\/doi.org\/10.1177\/13872877251376949","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,12]]}}}