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Recently, alterations in the mesolimbic system have been described, especially in the nucleus accumbens (nAc). We found that intracellular accumulation of A\u03b2 was higher in neurons of the APP\/PS1 mice at 10 and 15 days\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    . At 15 days\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    (DIV), APP\/PS1 accumbal neurons showed alterations in synaptic transmission and neuronal excitability. Specifically, there was an increase in AMPAergic synaptic currents, which was sensitive to the application of NASPM, suggesting a critical role for calcium-permeable AMPA receptors (CP-AMPARs). Our study indicates that this neuronal culture model accurately replicates alterations in the early stages of AD.\n                  <\/jats:p>","DOI":"10.1177\/13872877251378468","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T14:18:29Z","timestamp":1758723509000},"page":"531-538","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Alterations in neuronal excitability and AMPA-mediated neurotransmission in an APP\/PS1 neuronal culture model derived from nucleus accumbens"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1825-6898","authenticated-orcid":false,"given":"Paulina","family":"Saavedra-Sieyes","sequence":"first","affiliation":[{"name":"Laboratorio de Neurofisiolog\u00eda, Departamento de Fisiolog\u00eda, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9331-4515","authenticated-orcid":false,"given":"Isa\u00edas","family":"Meza","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofisiolog\u00eda, Departamento de Fisiolog\u00eda, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3433-2014","authenticated-orcid":false,"given":"Nicol\u00e1s","family":"Riffo-Lepe","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofisiolog\u00eda, Departamento de Fisiolog\u00eda, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loreto","family":"San Martin","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofisiolog\u00eda, Departamento de Fisiolog\u00eda, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"},{"name":"Programa de Neurociencia, Psiquiatr\u00eda y Salud Mental (NEPSAM), Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9158-2218","authenticated-orcid":false,"given":"Juliana","family":"Gonz\u00e1lez-SanMiguel","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofisiolog\u00eda, Departamento de Fisiolog\u00eda, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3160-1522","authenticated-orcid":false,"given":"Luis G","family":"Aguayo","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofisiolog\u00eda, Departamento de Fisiolog\u00eda, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"},{"name":"Programa de Neurociencia, Psiquiatr\u00eda y Salud Mental (NEPSAM), Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.741"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606210"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3381"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.06.018"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.01.016"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00399"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14727"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76456-w"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-1605-3"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.1016559"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.199"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh019"},{"key":"e_1_3_3_14_2","first-page":"269","article-title":"Micro-dissection of rat brain for RNA or protein extraction from specific brain region","volume":"7","author":"Chiu K","year":"2007","unstructured":"Chiu K, Lau WM, Lau HT, et al. 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