{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T10:18:56Z","timestamp":1779099536987,"version":"3.51.4"},"reference-count":51,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the research funding for longevity sciences","award":["26-30"],"award-info":[{"award-number":["26-30"]}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23ae0101077"],"award-info":[{"award-number":["JP23ae0101077"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23dk0207052"],"award-info":[{"award-number":["JP23dk0207052"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) frequently causes epilepsy and myoclonus. These symptoms are thought to be associated with neuronal hyperexcitability, highlighting the need for biomarkers that reflect synaptic functional alterations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to examine changes in neuronal excitability associated with AD progression using magnetoencephalography (MEG). Furthermore, we investigated the relationship between alterations in electromagnetic signals and other neuroimaging biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We measured middle-latency somatosensory evoked magnetic fields (m-SEFs) following right median nerve stimulation in 45 individuals, comprising 6, 8, and 31 individuals with AD dementia (ADD), mild cognitive impairment (MCI), and cognitively healthy older adults, respectively. Cortical reactivity relative to the primary somatosensory response (N20\u2005m) was assessed using normalized m-SEF waveforms. Additionally, we analyzed associations between these waveforms and amyloid-\u03b2 (A\u03b2) deposition, regional glucose metabolism, and gray matter volume using positron-emission tomography and magnetic resonance imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The m-SEF waveform exhibited six components (M2\u2013M7) within 150\u2005ms of the N20\u2005m (M1) response. The m-SEF waveforms tended to be enlarged in ADD and MCI, with a significant enhancement of M2 in ADD. The amplitude of M7 at approximately 100\u2005ms latency was significantly and positively correlated with local A\u03b2 deposition in the sensorimotor cortex. Moreover, regional glucose hypometabolism in the hippocampus and pulvinar was significantly associated with enlargement of the M4, M6, and M7 components.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings indicate that cortical responses to somatosensory stimulation are modulated by AD progression. M-SEF may serve as a potential marker for evaluating cortical excitability in the sensorimotor cortex.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251379466","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T19:04:41Z","timestamp":1758913481000},"page":"862-872","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Modulation of middle-latency somatosensory evoked magnetic field waveforms associated with the pathophysiological states of Alzheimer's disease"],"prefix":"10.1177","volume":"108","author":[{"given":"Emi","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Biomarker Research, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nihashi","sequence":"additional","affiliation":[{"name":"Department of Biomarker Research, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan"},{"name":"Department of Radiology, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan"},{"name":"Department of Clinical and Experimental Neuroimaging, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7810-8984","authenticated-orcid":false,"given":"Yutaka","family":"Arahata","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinori","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsunori","family":"Yokoi","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Neuroimaging, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kersten","family":"Diers","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burkhard","family":"Maess","sequence":"additional","affiliation":[{"name":"Brain Networks group, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4259-1297","authenticated-orcid":false,"given":"Akinori","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Biomarker Research, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan"},{"name":"Department of Clinical and Experimental Neuroimaging, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-021-00520-w"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170031"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.9.1226"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.07.025"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1162844"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/280289"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3801"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2018.00060"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1103\/RevModPhys.65.413"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0332"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy044"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06876-8"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(99)00063-5"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1999.0470"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh043"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(83)90055-6"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00718016"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-009-0343-5"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_3_3_26_2","first-page":"29","article-title":"Voxel-based morphometry of brain MRI in normal aging and Alzheimer's disease","volume":"4","author":"Matsuda H","year":"2013","unstructured":"Matsuda H. Voxel-based morphometry of brain MRI in normal aging and Alzheimer's disease. Aging Dis 2013; 4: 29\u201337.","journal-title":"Aging Dis"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.007"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31823b9c5e"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.90.353"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-141338"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/51\/7\/008"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnp.2024.04.002"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/110.5.1359"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(93)90183-V"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1177\/1060028014550334"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.2.345"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.5041\/RMMJ.10510"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy093"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.12.1791"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.946297"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5215-08.2009"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2014.04.010"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23158"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-008-0129-1"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.3233\/ADR-200286"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51815"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn185"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001276"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1116002"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2014.00083"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(05)49015-9"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251379466","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877251379466","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251379466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T09:35:22Z","timestamp":1779096922000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877251379466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,26]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1177\/13872877251379466"],"URL":"https:\/\/doi.org\/10.1177\/13872877251379466","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,26]]}}}