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Outcomes included cognitive domain scores (e.g., episodic memory, language), magnetic resonance imaging (MRI) (e.g., hippocampal and white matter hyperintensity volume), and blood-based biomarkers (e.g., A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      , pTau-217, NfL, GFAP). Sociodemographics included age, sex, racial group, Hispanic ethnicity, primary language, nativity, socioeconomic position, area deprivation, and living alone. Multivariable linear regression examined associations between sociodemographics and brain health outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean age was 69\u2009\u00b1\u20099 and 71% were women. Older individuals, women, Black and Hispanic individuals, those of lower socioeconomic position, and those born outside the US performed worse across various cognitive domains, while those who primarily spoke Spanish (versus English) scored better on episodic memory. Older individuals, women, and Hispanic individuals had worse brain health, and those identifying as other racial group and born outside of the US had better brain health measured via MRI. Older and Hispanic individuals had worse brain health and Black individuals and women had better brain health as measured via blood-based biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study contributes to the growing number of studies identifying differences in ADRD\/vascular biomarkers by sociodemographics. Additional studies are needed to assess whether social and economic determinants of health are associated with longitudinal change in ADRD\/vascular biomarkers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251386378","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:54:48Z","timestamp":1760550888000},"page":"1243-1256","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Sociodemographic correlates of cognition and Alzheimer's disease and vascular biomarkers among middle to older age participants in the Healthy Brain Initiative"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9945-0877","authenticated-orcid":false,"given":"Lilah M","family":"Besser","sequence":"first","affiliation":[{"name":"Comprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Boca 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