{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T15:31:06Z","timestamp":1793979066283,"version":"4.8.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Lina Ma","award":["Beijing Natural Science Foundation"],"award-info":[{"award-number":["Beijing Natural Science Foundation"]}]},{"name":"Lina Ma","award":["NO. 7232314"],"award-info":[{"award-number":["NO. 7232314"]}]},{"name":"Hao Li","award":["the National key Research and Development Program"],"award-info":[{"award-number":["the National key Research and Development Program"]}]},{"name":"Hao Li","award":["2022YFC3501400"],"award-info":[{"award-number":["2022YFC3501400"]}]},{"name":"Hao Li","award":["NO.82474464"],"award-info":[{"award-number":["NO.82474464"]}]},{"name":"Hao Li","award":["the National Natural Science Foundation of China"],"award-info":[{"award-number":["the National Natural Science Foundation of China"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Motoric cognitive risk syndrome (MCR) is a newly identified pre-dementia (e.g., for Alzheimer's disease) syndrome characterized by the coexistence of gait slowing and subjective cognitive complaint.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigates the association of activities of daily living (ADL) with MCR and the mediating effect of depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used data from the 2011\u20132015 waves of CHARLS. ADL was measured at baseline, including basic ADL (BADL) and instrumental ADL (IADL). MCR was defined as subjective cognitive complaint plus objectively measured gait slowing. Depression was assessed using the Center for Epidemiologic Studies Depression Scale-10. Logistic regression and Cox proportional hazards models assessed cross-sectional and longitudinal associations between ADL dysfunction and MCR. Mediation analysis assessed the mediating role of depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the cross-sectional analysis, 4937 participants were included, with a prevalence of MCR of 12.8%. All models revealed that dysfunction in ADL, BADL, and IADL was significantly associated with an increased likelihood of MCR. In the follow-up analysis, MCR prevalence was 6.8% among 3953 participants. Similarly, in all models, dysfunction in ADL, BADL, and IADL remained significantly associated with a higher risk of MCR. Mediation analysis showed that depression explained 36.8%, 50.3%, and 34.2% of the associations of ADL, BADL, and IADL dysfunction with MCR risk, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study suggests that early identification of ADL dysfunction and depression may help facilitate interventions to reduce the incidence of MCR in older adults and mitigate the progression of cognitive decline to dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251386380","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:23:30Z","timestamp":1760646210000},"page":"1257-1267","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between activities of daily living and motoric cognitive risk syndrome in Chinese older adults: The mediating effect of depression"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4617-3973","authenticated-orcid":false,"given":"Luping","family":"Wang","sequence":"first","affiliation":[{"name":"Wangjing Hospital, China Academy of Chinese Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinye","family":"Ma","sequence":"additional","affiliation":[{"name":"Wangjing Hospital, China Academy of Chinese Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Ma","sequence":"additional","affiliation":[{"name":"Xiyuan Hospital, China Academy of Chinese Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Pei","sequence":"additional","affiliation":[{"name":"Xiyuan Hospital, China Academy of Chinese Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"He","sequence":"additional","affiliation":[{"name":"Wangjing Hospital, China Academy of Chinese Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Wangjing Hospital, China Academy of Chinese Medical Sciences"},{"name":"Xiyuan Hospital, China Academy of Chinese Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"Dementia","author":"World Health Organization","year":"2025","unstructured":"World Health Organization. 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