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The interactive effect of ARV and ASI on medial temporal lobe atrophy, plasma neurofilament light chain (NfL), and plasma glial fibrillary acidic protein (GFAP) was studied using hierarchical linear regression in older adults\n                      <jats:italic toggle=\"yes\">.<\/jats:italic>\n                      Voxel-based morphometry was used to confirm region-of-interest analysis findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The interaction between higher ARV and higher ASI was significantly associated with left-sided medial temporal lobe atrophy in both the region-of-interest (left hippocampus \u03b2\u2009=\u2009\u2212252.79, p\u2009=\u20090.0002, right hippocampus \u03b2\u2009=\u2009\u2212193.56, p\u2009=\u20090.001, left entorhinal cortex \u03b2\u2009=\u2009\u22120.13, p\u2009=\u20090.007), and false discovery rate-corrected voxel-based morphometry analysis (p\u2009=\u20090.03). The interactive effect was also significantly associated with increased plasma NfL (\u03b2\u2009=\u20093.88, p\u2009=\u20090.01), but not GFAP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The interaction between ARV and ASI is independently associated with neurodegenerative markers, including medial temporal lobe atrophy and plasma NfL, in older adults. These findings suggest that greater hemodynamic instability is associated with increased risk for neurodegenerative processes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251386443","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T16:58:57Z","timestamp":1760720337000},"page":"1276-1286","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Blood pressure dynamic instability and neurodegeneration in older adults"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9634-702X","authenticated-orcid":false,"given":"Trevor","family":"Lohman","sequence":"first","affiliation":[{"name":"University of Southern California, Leonard Davis School of Gerontology, Los Angeles, CA, 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