{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:21:01Z","timestamp":1777396861274,"version":"3.51.4"},"reference-count":53,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) imposes substantial societal and healthcare burdens. Emerging evidence links poor oral hygiene to AD risk, but further research is still required to clarify this link.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the associations between dental floss use, regular dental visits, and their combined effects on 5-year AD risk among United States (US) adults aged \u226565.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional analysis included 3356 adults aged 65\u2009+\u2009from NHANES (2013\u20132018). Predicted five-year AD risk scores (0\u201344) combined sociodemographic, psychological, behavioral, and medical factors, categorized as low (0\u201320) or high risk (21\u201344) groups. Dental floss use and past-year dental visits were assessed. Associations were evaluated using weighted logistic regression models to account for complex survey design and US representativeness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher rates of dental floss use and past-year dental visits were each associated with lower predicted 5-year AD risk scores. After adjustment, flossing reduced the odds of high predicted risk by 32% (OR\u2009=\u20090.68, 95% CI: 0.56\u20130.84) and dental visits by 28% (OR\u2009=\u20090.72, 95% CI: 0.58\u20130.90). Compared to those with neither behavior, participants who flossed alone (OR\u2009=\u20090.63, 95% CI: 0.48\u20130.83), had dental visits only (OR\u2009=\u20090.69, 95% CI: 0.52\u20130.92), or engaged in both behaviors (OR\u2009=\u20090.58, 95% CI: 0.45\u20130.74) showed progressively lower odds of being classified in the high predicted risk group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Regular dental flossing and visits were independently associated with reduced predicted 5-year AD risk, with partially additive effects when combined, supporting routine oral hygiene promotion as a potential preventive strategy in older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251386836","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:40:18Z","timestamp":1760647218000},"page":"1410-1421","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between dental floss use, dental visits, and a five-year Alzheimer's disease risk prediction score among United States adults aged 65 years and older"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5526-5681","authenticated-orcid":false,"given":"Minghao","family":"Zou","sequence":"first","affiliation":[{"name":"The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1110-8765","authenticated-orcid":false,"given":"Hairui","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6815-6568","authenticated-orcid":false,"given":"You","family":"Lu","sequence":"additional","affiliation":[{"name":"Center for Aging, School of Medicine, Tulane University, New Orleans, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee","family":"Underwood","sequence":"additional","affiliation":[{"name":"Kinesiology and Health Studies Department, Southeastern Louisiana University, Hammond, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tung-Sung","family":"Tseng","sequence":"additional","affiliation":[{"name":"Behavioral and Community Health Sciences, School of Public Health, Louisiana State University Health Sciences Center-New Orleans, New Orleans, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9353-3671","authenticated-orcid":false,"given":"Susu","family":"Luo","sequence":"additional","affiliation":[{"name":"The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Shanghai, China"},{"name":"Moores Cancer Center, School of Medicine, University of California San Diego, La Jolla, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_3_4_3_2","volume-title":"Risk reduction of cognitive decline and dementia: WHO guidelines","author":"World Health Organization","year":"2019","unstructured":"World Health Organization. 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