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As such, we reveal potential binding sites for ergot alkaloids, steroids, retinoids, antivirals, angiotensin receptor blockers, and Neurokinin 1 (NK1) receptor antagonists on multiple AD targets. Importantly, the therapeutic potential of the top-scoring ligands is confounded by pharmacokinetics and adverse-effects. For example, poor blood-brain barrier (BBB) penetration, and vasoconstriction, discount ergot-alkaloid use in AD. Likewise, potential toxicity limits prolonged use of steroids, Nilotinib, Adapalene, and Irinotecan. Conversely, BBB penetration, neuronal protection, oral availability, anti-inflammation, and anti-hypertension, admit Angiotensin receptor blockers (ARB), (Telmisartan\/Candesartan); Antidiuretic hormone (ADH) inhibitors (Conivaptan\/Tolvaptan); and of the NK1 receptors antagonists (Rolapitant\/Netupitant) use in AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our multitarget screening identifies selective synergistic AD modulators, such as ARB, ADH and NK1 receptor inhibitors, and simplifies drug discovery by focusing on the most promising candidates for experimental validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251387167","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T18:52:52Z","timestamp":1761245572000},"page":"1088-1103","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Virtual screening of drugs against multiple targets of Alzheimer's disease"],"prefix":"10.1177","volume":"108","author":[{"given":"Karin","family":"Ben Zaken","sequence":"first","affiliation":[{"name":"Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8262-061X","authenticated-orcid":false,"given":"Samuel","family":"Mesfin","sequence":"additional","affiliation":[{"name":"Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naamah","family":"Bloch","sequence":"additional","affiliation":[{"name":"Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7436-3515","authenticated-orcid":false,"given":"Abraham O","family":"Samson","sequence":"additional","affiliation":[{"name":"Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"1","volume-title":"Alzheimer\u2019s disease","author":"Polis B","year":"2019","unstructured":"Polis B, Samson AO. 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