{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:17:00Z","timestamp":1780669020240,"version":"3.54.1"},"reference-count":47,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160258"],"award-info":[{"award-number":["82160258"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangxi Natural Science Foundation","award":["2023GXNSFBA026173"],"award-info":[{"award-number":["2023GXNSFBA026173"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2403504"],"award-info":[{"award-number":["2022YFC2403504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guilin technology application and promotion plan","award":["202201397-4"],"award-info":[{"award-number":["202201397-4"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer-associated neuronal thread protein (AD7c-NTP) has emerged as a potential diagnostic biomarker for Alzheimer's disease (AD) and mild cognitive impairment (MCI). Growing research indicates neuroinflammatory mechanisms contribute to AD pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the relationship between AD7c-NTP level and inflammatory biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study enrolled 112 participants comprising 72 cognitively impaired individuals (CI group) and 40 demographically matched controls with cognitively normal (CN group). Comprehensive physical evaluations and standardized neuropsychological assessments were administered. Urinary AD7c-NTP concentrations were quantified through enzyme-linked immunosorbent assay (ELISA), while plasma levels of twelve inflammatory markers\u2014IL-1\u03b2, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-17A, TNF-\u03b1, IFN-\u03b1, and IFN-\u03b3\u2014were analyzed via flow cytometry-based immunofluorescence techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Concentrations of IL-2, IFN-\u03b1, and IFN-\u03b3 showed marked elevation in CI patients relative to CN controls (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.005, 0.008, and 0.010, respectively). Strong positive associations emerged between AD7c-NTP concentrations and both IL-2 (r\u2009=\u20090.492,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and IFN-\u03b1 (r\u2009=\u20090.492,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The four-marker panel (AD7c-NTP combined with IL-2, IFN-\u03b1, and IFN-\u03b3) achieved optimal diagnostic accuracy for cognitive impairment, yielding an AUC value of 0.9774 with 94% sensitivity and 75% specificity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Integrating IL-2, IFN-\u03b1, and IFN-\u03b3 measurements with AD7c-NTP detection could constitute a superior diagnostic framework for early-stage cognitive decline. The observed correlations between AD7c-NTP and these cytokine profiles may indicate previously unrecognized metabolic pathways relevant to AD pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251389239","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T19:34:48Z","timestamp":1761334488000},"page":"1593-1601","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The association between Alzheimer-associated neuronal thread protein (AD7c-NTP) and plasma inflammatory cytokine levels in individuals with cognitive impairment and demographically-matched controls"],"prefix":"10.1177","volume":"108","author":[{"given":"He","family":"Jin","sequence":"first","affiliation":[{"name":"Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"He","sequence":"additional","affiliation":[{"name":"Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemin","family":"Wang","sequence":"additional","affiliation":[{"name":"Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Health Management Center, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chu","sequence":"additional","affiliation":[{"name":"Health Management Center, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[{"name":"Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Geriatric Medical Research Center, Beijing, China"},{"name":"Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12626"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70194-7"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2310168"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-01104-7"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells11121885"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-00435-y"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-022-01721-1"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1117172"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02565-0"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119864"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2825(1998)12:5<285::AID-JCLA6>3.0.CO;2-5"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1162\/15268740252769709"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2006.07.002"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2014.10.011"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170383"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201273"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000905"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/60.2.195"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02853-3"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-S011"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.039"},{"key":"e_1_3_3_25_2","article-title":"Hospital anxiety and depression scale exhibits good consistency but shorter assessment time than Zung self-rating anxiety\/depression scale for evaluating anxiety\/depression in non-small cell lung cancer","volume":"100","author":"Guo C","year":"2021","unstructured":"Guo C, Huang X. Hospital anxiety and depression scale exhibits good consistency but shorter assessment time than Zung self-rating anxiety\/depression scale for evaluating anxiety\/depression in non-small cell lung cancer. Medicine (Baltimore) 2021; 100: e24428.","journal-title":"Medicine (Baltimore)"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0270095"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610218000674"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-240148"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)00062-4"},{"key":"e_1_3_3_31_2","article-title":"Mini-Mental State Examination (MMSE) for the early detection of dementia in people with mild cognitive impairment (MCI)","volume":"7","author":"Arevalo-Rodriguez I","year":"2021","unstructured":"Arevalo-Rodriguez I, Smailagic N, Roqu\u00e9-Figuls M, et al. Mini-Mental State Examination (MMSE) for the early detection of dementia in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev 2021; 7: CD010783.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09506-7"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-021-03495-6"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21856"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190401"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220451"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1177\/15333175221115247"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2022.102575"},{"key":"e_1_3_3_39_2","first-page":"170","article-title":"Raised serum proinflammatory cytokines in Alzheimer's disease with depression","volume":"5","author":"Khemka VK","year":"2014","unstructured":"Khemka VK, Ganguly A, Bagchi D, et al. Raised serum proinflammatory cytokines in Alzheimer's disease with depression. Aging Dis 2014; 5: 170\u2013176.","journal-title":"Aging Dis"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.963845"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aat1482"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-221081"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2015.01.002"},{"key":"e_1_3_3_44_2","article-title":"The role of JAK-STAT signaling within the CNS","volume":"2","author":"Nicolas CS","year":"2013","unstructured":"Nicolas CS, Amici M, Bortolotto ZA, et al. The role of JAK-STAT signaling within the CNS. JAKSTAT 2013; 2: e22925.","journal-title":"JAKSTAT"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.670115"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2008.02.002"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12399"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1177\/1533317519880369"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251389239","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877251389239","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251389239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T13:46:30Z","timestamp":1780667190000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877251389239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,24]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1177\/13872877251389239"],"URL":"https:\/\/doi.org\/10.1177\/13872877251389239","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,24]]}}}