{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:16:29Z","timestamp":1780668989649,"version":"3.54.1"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Danish Dementia Research Centre","award":["The project is funded through the Danish Dementia"],"award-info":[{"award-number":["The project is funded through the Danish Dementia"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dementia is associated with increased mortality, yet limited data exist on cause-specific life years lost (LYL) in large national populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To quantify excess all-cause and cause-specific mortality, including life years lost, among older adults with dementia in Denmark using nationwide data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a register-based cohort study of over 2.3 million individuals aged 65+, including 191,038 individuals diagnosed with dementia. Using state-of-the-art LYL methodology, we compared mortality rate ratios (MRRs) and LYL between people with and without dementia, stratified by age and sex, with follow-up covering 22.6 million person-years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Females and males with dementia had adjusted all-cause MRRs of 2.88 (95% CI: 2.86\u20132.90) and 3.15 (95% CI: 3.12\u20133.17), respectively, compared to those without. The average cause-specific LYL among individuals with dementia was 3.73 years (95% CI: 3.71\u20133.76) for females and 3.96 years (95% CI: 3.93\u20133.98) for males. Dementia as the underlying cause of death accounted for the majority of life years lost among individuals with dementia, while other major causes of death, such as cancer and heart disease, were associated with fewer lost years compared to the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings underscore the substantial mortality burden associated with dementia among older adults in Denmark. Recognizing dementia as a life-threatening condition highlights the urgent need for targeted public health and policy responses. Including LYL in prognostic considerations may also improve clinical care planning and support services following diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251389963","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T18:50:29Z","timestamp":1761936629000},"page":"1717-1725","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dementia in Denmark: Uncovering the causes of death and life years lost in a nationwide, register-based cohort study"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6934-1784","authenticated-orcid":false,"given":"Thomas Munk","family":"Laursen","sequence":"first","affiliation":[{"name":"Aarhus Universitet, National Centre for Register-based Research, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Feodor","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Psychiatric Centre Copenhagen, Hellerup Hospital, Hellerup, Capital Region of Denmark, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten B\u00f8cker","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Aarhus Universitet, National Centre for Register-based Research, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunhild","family":"Waldemar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Dementia Research Centre, Copenhagen, Capital Region of Denmark, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1605-3396","authenticated-orcid":false,"given":"Janet","family":"Janbek","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Dementia Research Centre, Copenhagen, Capital Region of Denmark, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Dementia in Denmark. https:\/\/videnscenterfordemens.dk\/en\/dementia-denmark (2024 accessed August 2024)."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200823"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.07.006"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12764"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12901"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2024.101189"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01296-0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2019.07.002"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000306055"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150946"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000362926"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.17345"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/1471301216659797"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-221290"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13016"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811401482"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810395825"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394717"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811399958"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-4348-9"},{"key":"e_1_3_3_23_2","unstructured":"Carstensen B. Demography and epidemiology: Practical use of the Lexis diagram in the computer age \u2013 or: Who needs the Cox-model anyway? https:\/\/bendixcarstensen.com\/Papers\/Carstensen.2006b.pdf (2006)."},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0228073"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-78665-0_18"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3206594"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-191117"},{"key":"e_1_3_3_28_2","unstructured":"Dementia Care Central. Life Expectancy Calculator for Alzheimer\u2019s Disease & Dementia https:\/\/www.dementiacarecentral.com\/aboutdementia\/life-expectancy-calculator\/ (2023 accessed October 08 2024)."},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2014.301935"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610211002924"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13114"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13835"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13019"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251389963","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877251389963","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251389963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T13:45:20Z","timestamp":1780667120000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877251389963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,31]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1177\/13872877251389963"],"URL":"https:\/\/doi.org\/10.1177\/13872877251389963","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,31]]}}}