{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:16:08Z","timestamp":1780668968532,"version":"3.54.1"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"KLEF","award":["KLEF-002"],"award-info":[{"award-number":["KLEF-002"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\u03b1-Synuclein (\u03b1-syn) is a prominent protein associated with neurodegenerative conditions such as Parkinson's disease (PD), dementia, and multiple system atrophy, and is a key player in synucleinopathies. Despite its significance, the specific changes in \u03b1-syn fibril conformations during the progression of PD remain a subject of uncertainty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigates the structural alterations in \u03b1-syn aggregation from cerebrospinal fluid samples at different PD stages (pre-PD, mid-PD, and late-PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In the present study, we used multifractal detrended fluctuation analysis (MFDFA) and persistent homology. The analysis involves constructing protein contact networks for major and minor \u03b1-syn polymorphs. The subsequent application of MFDFA to vertex degree, vertex clustering coefficients, and vertex closeness centrality on this time series data reveals multifractal properties and scaling behaviors. Simultaneously, topological analyses, including Rips complexes, Alpha complexes, and Betti numbers, uncover essential structural features and connectivity patterns in \u03b1-syn networks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study illuminates \u03b1-syn multifractal dynamics and topological characteristics, providing valuable insights into disease-related protein aggregation and network alterations in the progression of PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides unique information on MFDFA and persistent homology of \u03b1-syn aggregates across disease stages.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251390838","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T15:33:53Z","timestamp":1762356833000},"page":"1875-1893","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multifractal detrended fluctuation analysis and persistent homology of \u03b1-synuclein aggregates across Parkinson's disease stages"],"prefix":"10.1177","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0083-0579","authenticated-orcid":false,"given":"Pranathi","family":"Jalapally","sequence":"first","affiliation":[{"name":"Department of Computer Science and Engineering, APJ Abdul Kalam Technological University, Thiruvananthapuram, India"},{"name":"Department of Computer Science and Engineering, Rajagiri School of Engineering &amp; Technology (Autonomous), Kochi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0717-2265","authenticated-orcid":false,"given":"Lakshmi Sowmya","family":"Emani","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Koneru Lakshmaiah Education Foundation Deemed to be University, Vaddeswaram, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1058-0737","authenticated-orcid":false,"given":"Sminu","family":"Izudheen","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Rajagiri School of Engineering &amp; Technology (Autonomous), Kochi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4801-3535","authenticated-orcid":false,"given":"Jagannatha Rao","family":"K S","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Koneru Lakshmaiah Education Foundation Deemed to be University, Vaddeswaram, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-4-9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00568-3"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.131045"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05672-9"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8327-0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2003.10506918"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-022-00357-0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.14802\/jmd.24075"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26115405"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/clinpract15060107"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/clinpract15030065"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2022.11.013"},{"key":"e_1_3_3_14_2","first-page":"669","article-title":"Parkinson\u2019s disease drug therapies in the clinical trial pipeline: 2024 update","volume":"14","author":"McFarthing K","year":"2024","unstructured":"McFarthing K, Rafaloff G, Baptista M, et al. Parkinson\u2019s disease drug therapies in the clinical trial pipeline: 2024 update. 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