{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:22:29Z","timestamp":1777396949602,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Midlife marks a critical period for detecting Alzheimer's disease (AD) risk because biological and lifestyle factors exceedingly influence brain aging. Konishi et al. used functional magnetic resonance imaging to examine sex differences and risk factors (apolipoprotein E\n                    <jats:italic toggle=\"yes\">(APOE)<\/jats:italic>\n                    \u03b54, hypertension, type 2 diabetes, depression) on memory-related brain activity starting in midlife. High-risk women showed greater hippocampal hyperactivity, amyloid-\u03b2 accumulation, and memory deficits than other groups. However, limited sample diversity, lack of tau imaging, unmeasured hormonal levels, and vascular influences constrain interpretations. These findings emphasize the need for sex-informed, mechanistically precise approaches in AD research targeting preclinical stages of disease progression.\n                  <\/jats:p>","DOI":"10.1177\/13872877251392238","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T15:36:33Z","timestamp":1762356993000},"page":"97-99","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Midlife brain vulnerability: Sex differences in functional magnetic resonance imaging and Alzheimer's disease risk"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1395-2355","authenticated-orcid":false,"given":"Alin","family":"Alshaheri Durazo","sequence":"first","affiliation":[{"name":"Department of Psychology, Binghamton University, Binghamton, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0907-8931","authenticated-orcid":false,"given":"Ian M","family":"McDonough","sequence":"additional","affiliation":[{"name":"Department of Psychology, Binghamton University, Binghamton, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01296-0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-024-00692-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5062-08.2009"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv338"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/13607863.2018.1531383"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/35084005"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251366701"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-86397-7"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1037\/pag0000606"},{"key":"e_1_3_3_11_2","article-title":"Expanding the scope of health disparities research in Alzheimer's disease and related dementias: prioritizing race, ethnicity, sex, socioeconomic status, disability, and gender identity","volume":"19","author":"Masoudi P","year":"2023","unstructured":"Masoudi P, Matsumoto N, Tinetti ME. Expanding the scope of health disparities research in Alzheimer's disease and related dementias: prioritizing race, ethnicity, sex, socioeconomic status, disability, and gender identity. Alzheimers Dement 2023; 19: e02887.","journal-title":"Alzheimers Dement"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad232"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-024-03073-w"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185926"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.056666"},{"key":"e_1_3_3_16_2","doi-asserted-by":"crossref","unstructured":"McDonough IM Bender A Patihis L et al. Interpreting fMRI studies in populations with cerebrovascular risk: the use of a subject-specific hemodynamic response function. Behav Sci 2025; 15: 1457.","DOI":"10.3390\/bs15111457"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101133"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1246"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.113"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251392238","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877251392238","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251392238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:09:33Z","timestamp":1777370973000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877251392238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,5]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/13872877251392238"],"URL":"https:\/\/doi.org\/10.1177\/13872877251392238","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,5]]}}}