{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:22:03Z","timestamp":1777396923252,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG062428"],"award-info":[{"award-number":["P30 AG062428"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG072959"],"award-info":[{"award-number":["P30 AG072959"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Logopenic primary progressive aphasia (LPA) is often associated with Alzheimer's disease (AD) pathology. However, few studies have compared cortical atrophy patterns in LPA and AD and their association with cognitive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify atrophy patterns specific to LPA and determine whether those patterns relate to deficits in specific cognitive domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Electronic health records from 2014\u20132024 were retrospectively reviewed to identify patients with LPA who had undergone MRI and neuropsychological (NP) examinations. Patients with LPA (n\u2009=\u200926) were matched in terms of age, sex, education, and symptom duration to patients with amnestic mild cognitive impairment (aMCI; n\u2009=\u200913). Logistic regression was used to assess group differences in MRI measures of cortical volume and thickness. Cluster analysis was used to identify patterns of atrophy that were associated with specific cognitive domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The LPA group performed significantly worse than the aMCI group on NP measures assessing verbal learning, attention\/working memory, language, and executive functioning (p\u2009&lt;\u20090.05). Compared to the aMCI group, the LPA group demonstrated both smaller and thinner cortex in the left lateral aspect of the superior temporal gyrus, superior temporal sulcus, and fusiform gyrus (p\u2009&lt;\u20090.05), with the left superior temporal sulcus providing the most accurate measure of discrimination. Severity of language related cognitive deficits was not associated with a specific cluster in the LPA group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with LPA demonstrate specific patterns of cortical atrophy that are distinguishable from atrophy due to aMCI and may be useful for diagnostic purposes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251392928","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T17:59:32Z","timestamp":1763402372000},"page":"179-188","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Patterns of cortical atrophy are associated with specific cognitive domains in patients with logopenic primary progressive aphasia"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1504-7130","authenticated-orcid":false,"given":"Katherine A","family":"Koenig","sequence":"first","affiliation":[{"name":"Diagnostic Institute, Cleveland Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Huang","sequence":"additional","affiliation":[{"name":"Diagnostic Institute, Cleveland Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Bonner-Jackson","sequence":"additional","affiliation":[{"name":"Cleveland Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James B","family":"Leverenz","sequence":"additional","affiliation":[{"name":"Cleveland Clinic"},{"name":"VA-Puget Sound Health Care System"},{"name":"University of Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7022-8436","authenticated-orcid":false,"given":"Mark J","family":"Lowe","sequence":"additional","affiliation":[{"name":"Diagnostic Institute, Cleveland Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagan A","family":"Pillai","sequence":"additional","affiliation":[{"name":"Cleveland Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821103e6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21388"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25333"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000320506.79811.da"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21451"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821ccd3c"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2012.12.008"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3233\/ADR-220010"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2016.10.019"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22927"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062471"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2019.12.026"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-019-04013-z"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11091209"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/1533317507307173"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-012-9203-2"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn113"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1214083"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00330"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5544-10.2011"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10825"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.12779\/dnd.2016.15.4.93"},{"key":"e_1_3_2_27_2","volume-title":"Wechsler memory scale","author":"Wechsler D","year":"2009","unstructured":"Wechsler D. Wechsler memory scale. 4th Edition. San Antonio, TX: Pearson, 2009.","edition":"4"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1076\/clin.12.1.43.1726"},{"key":"e_1_3_2_29_2","volume-title":"Wechsler adult intelligence scale","author":"Wechsler D","year":"2008","unstructured":"Wechsler D. Wechsler adult intelligence scale. 4th Edition. San Antonio, TX: Psychological Corporation, 2008.","edition":"4"},{"key":"e_1_3_2_30_2","volume-title":"Boston naming test","author":"Kaplan E","year":"2001","unstructured":"Kaplan E, Goodglass H, Weintraub S. Boston naming test. 2nd Ed. Austin, TX: Pro-Ed, 2001.","edition":"2"},{"key":"e_1_3_2_31_2","volume-title":"Brief visuospatial memory test - revised: professional manual","author":"Benedict RH","year":"1997","unstructured":"Benedict RH. Brief visuospatial memory test - revised: professional manual. Odessa, FL: Psychological Assessment Resources, 1997."},{"key":"e_1_3_2_32_2","volume-title":"Delis\u2013Kaplan executive function system","author":"Delis DC","year":"2001","unstructured":"Delis DC, Kaplan E, Kramer JH. Delis\u2013Kaplan executive function system. San Antonio: The Psychological Corporation, 2001."},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201043"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.010"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.08.071"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.04.033"},{"key":"e_1_3_2_37_2","volume-title":"MATLAB version: 9.13.0 (R2022b)","author":"The MathWorks Inc","year":"2022","unstructured":"The MathWorks Inc. MATLAB version: 9.13.0 (R2022b). Natick, MA: The MathWorks Inc, 2022."},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.3102\/10769986025001060"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1214\/ss\/1032280214"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0377-0427(87)90125-7"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190124"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-122335"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617715000399"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251392928","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877251392928","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251392928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:09:35Z","timestamp":1777370975000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877251392928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,17]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/13872877251392928"],"URL":"https:\/\/doi.org\/10.1177\/13872877251392928","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,17]]}}}