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The relationship between sex, AD pathology, and complaints remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our study aims to (1) explore the relationship between A\u03b2 pathology, assessed with two complementary measures, and subjective cognitive complaints across multiple domains in cognitively unimpaired (CU) individuals and those with mild cognitive impairment (MCI); (2) assess which subjective cognitive complaints can differentiate A\u03b2-positive from A\u03b2-negative individuals, CU from MCI, and progressors from non-progressors; and (3) evaluate sex differences in these relationships.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In 418 CU older adults and 408 with MCI from the ADNI cohort, we examined associations between A\u03b2, subjective cognitive complaints and sex, controlling for age, education, depression, and anxiety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In CU individuals, higher A\u03b2 levels correlated with more severe language and visuospatial complaints. MCI individuals with elevated A\u03b2 reported more severe memory, language, and planning complaints. Memory, language, planning, and organization complaints predicted risk of MCI and clinical progression. Sex differences emerged in the association between A\u03b2 and visuospatial complaints, and in complaint types predicting A\u03b2 positivity and cognitive impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Subjective cognitive complaints in memory and non-memory domains (language, visuospatial, and executive functions) may signal cognitive decline risk due to their association with AD biomarkers and clinical progression. Sex differences highlight the need for personalized approaches in AD early diagnosis and disease progression monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251393268","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T16:54:47Z","timestamp":1762880087000},"page":"203-223","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Uncovering pathology, subjective cognitive complaints, and sex in early Alzheimer's disease"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6640-5114","authenticated-orcid":false,"given":"Sophie","family":"Boutin","sequence":"first","affiliation":[{"name":"Department of Psychology, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Centre de Recherche de l\u2019Institut Universitaire de G\u00e9riatrie de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4538-6245","authenticated-orcid":false,"given":"B\u00e9reng\u00e8re","family":"Houz\u00e9","sequence":"additional","affiliation":[{"name":"Department of Psychology, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Centre de Recherche de l\u2019Institut Universitaire de G\u00e9riatrie de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5218-3337","authenticated-orcid":false,"given":"Alexa","family":"Pichet Binette","sequence":"additional","affiliation":[{"name":"Centre de Recherche de l\u2019Institut Universitaire de G\u00e9riatrie de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Department of Pharmacology and Physiology, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9227-1443","authenticated-orcid":false,"given":"Simona Maria","family":"Brambati","sequence":"additional","affiliation":[{"name":"Department of Psychology, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"Centre de Recherche de l\u2019Institut Universitaire de G\u00e9riatrie de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70044-9"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.04.002"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.269"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68542-5"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.01.001"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30368-0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14835"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00618-1"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/1533317515592331"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005863"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170425"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2011.04.012"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.666"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-01138-w"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2016.12.005"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.09.002"},{"key":"e_1_3_3_19_2","article-title":"Self-reported word-finding complaints are associated with cerebrospinal fluid amyloid beta and atrophy in cognitively normal older adults","volume":"14","author":"Montembeault M","year":"2022","unstructured":"Montembeault M, Stijelja S, Brambati SM, et al. 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