{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:22:06Z","timestamp":1777396926055,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG051125"],"award-info":[{"award-number":["R01AG051125"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1AG088003"],"award-info":[{"award-number":["RF1AG088003"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG064948"],"award-info":[{"award-number":["U01AG064948"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Plasma neurodegenerative biomarkers are a potential low-cost tool for studying Alzheimer's disease and dementia in population-based research, especially in low- and middle-income countries. However, their associations with modifiable risk factors and utility as an outcome in epidemiologic studies remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our objective was to estimate the cross-sectional association between modifiable lifecourse risk factors for dementia and plasma-based neurodegenerative biomarkers, and to compare those with the associations between lifecourse risk factors and cognition in a population-representative Indian sample.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using nationally representative data from the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (N\u2009=\u20091625, average age 68.2 years), we estimated linear regressions to compare cross-sectional associations between lifecourse risk factors and both neurodegenerative biomarkers (amyloid-\u03b2 42\/40, total-tau, phosphorylated Tau181, glial fibrillary acidic protein, neurofilament light chain) and cognitive outcomes (general cognition, memory).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Despite significant associations between seven of thirteen risk factors and cognitive outcomes, associations between risk factors and neurodegenerative biomarkers were largely null with some exceptions; for example, hypertension (\u03b2\u2009=\u20090.17SD; 95% CI:0.08,0.26) and diabetes (\u03b2\u2009=\u20090.21SD; 95% CI:0.09, 0.32) were associated with higher neurofilament light chain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While we found expected associations between lifecourse risk factors for dementia and cognition, there was not strong evidence of cross-sectional associations between risk factors for dementia and plasma-based biomarkers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251393588","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T17:57:01Z","timestamp":1763488621000},"page":"380-388","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cross-sectional associations between lifecourse dementia risk factors, plasma neurodegenerative biomarkers, and cognition in older adults in India"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5497-9638","authenticated-orcid":false,"given":"Sarah","family":"Gao","sequence":"first","affiliation":[{"name":"Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alden L","family":"Gross","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2342-0780","authenticated-orcid":false,"given":"Leon M","family":"Aksman","sequence":"additional","affiliation":[{"name":"University of Southern California Stevens Neuroimaging and Informatics Institute, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masroor","family":"Anwar","sequence":"additional","affiliation":[{"name":"Department of Biophysics, All India Institute of Medical Sciences, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5459-5239","authenticated-orcid":false,"given":"Eileen M","family":"Crimmins","sequence":"additional","affiliation":[{"name":"Leonard Davis School of Gerontology, Andrus Gerontology Center, University of Southern California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4122-7415","authenticated-orcid":false,"given":"Sharmistha","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Biophysics, All India Institute of Medical Sciences, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Biophysics, All India Institute of Medical Sciences, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharat","family":"Thyagarajan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6209-719X","authenticated-orcid":false,"given":"Jinkook","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA"},{"name":"Department of Economics, University of Southern California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9005-3872","authenticated-orcid":false,"given":"Emma","family":"Nichols","sequence":"additional","affiliation":[{"name":"Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA"},{"name":"Leonard Davis School of Gerontology, Andrus Gerontology Center, University of Southern California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"5","article-title":"Global aging: the challenge of success","volume":"60","author":"Kinsella K","year":"2005","unstructured":"Kinsella K, Phillips DR. 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