{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:24:17Z","timestamp":1777397057940,"version":"3.51.4"},"reference-count":51,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["grant number 82171182"],"award-info":[{"award-number":["grant number 82171182"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Tianjin Scientific Research Projects in Key Areas of Traditional Chinese Medicine","award":["grant number 2025017"],"award-info":[{"award-number":["grant number 2025017"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The apolipoprotein E \u03b54 allele (\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54) is a genetic risk factor for neurodegenerative diseases. The potential of lipid metabolism as a biomarker in conjunction with\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 for the evaluation of dementia with Lewy bodies (DLB) warrants further investigation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The study aimed to investigate the association between\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 and lipid metabolism in DLB.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a cross-sectional observational study that included a total of 171 DLB patients diagnosed based on established clinical consensus criteria. Strict inclusion and exclusion criteria were used in this study.\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      genotypes and blood lipid levels were determined using unified standards. IBM SPSS Statistics software was used for statistical analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In patients with mild and moderate CDR,\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 carriers had significantly higher CHOL and LDL-C levels compared to non-carriers. In the 70\u201379 age group,\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 carriers demonstrated higher LDL-C (2.94\u2009\u00b1\u20090.83\u2005mmol\/L versus 2.47\u2009\u00b1\u20090.97\u2005mmol\/L,\n                      <jats:italic toggle=\"yes\">q<\/jats:italic>\n                      \u2009=\u20090.0480) and CHOL (4.88\u2009\u00b1\u20091.05\u2005mmol\/L versus 4.25\u2009\u00b1\u20091.18\u2005mmol\/L,\n                      <jats:italic toggle=\"yes\">q<\/jats:italic>\n                      \u2009=\u20090.0453) levels compared to non-carriers. In the 70\u201379 age group, ROC curve analysis showed that TG (AUC\u2009=\u20090.65, 95%CI\u2009=\u20090.514\u20130.785, p\u2009=\u20090.046), LDL-C (AUC\u2009=\u20090.663, 95%CI\u2009=\u20090.526\u20130.801, p\u2009=\u20090.03) and CHOL (AUC\u2009=\u20090.692, 95%CI\u2009=\u20090.557\u20130.827, p\u2009=\u20090.011) had certain reference value for diagnosis. Among patients presenting with rapid eye movement sleep behavior disorder, fluctuating cognition, and parkinsonism,\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 carriers exhibited higher levels of APO B, CHOL, and LDL-C compared to non-carriers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Peripheral blood lipid level as a metabolic biomarker, combined with\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 gene detection, has potential value for disease monitoring and prognosis evaluation.\n                    <\/jats:p>\n                  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