{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:22:55Z","timestamp":1777396975368,"version":"3.51.4"},"reference-count":54,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2009550"],"award-info":[{"award-number":["GNT2009550"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["23AARF-1025519"],"award-info":[{"award-number":["23AARF-1025519"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Apolipoprotein E (\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      ) \u025b4 carriage is the strongest genetic risk factor for sporadic Alzheimer's disease dementia. Clinical guidelines discourage\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      disclosure, but therapeutic advances are changing this. Limited work has assessed knowledge and interest in\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      disclosure in Australian adults, and it remains unclear which characteristics are associated with interest within this sample.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study examines knowledge and interest in\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      disclosure among Australian adults. Based on previous estimates, it was hypothesized that \u226550% would be interested in\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      disclosure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Cognitively unimpaired middle- and older-aged adults (N\u2009=\u20091421) completed the Knowledge, Interest and Preferences for\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      Testing and Disclosure survey, measuring\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      knowledge, interest in\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      disclosure, and perceived benefits\/concerns. Participants completed online assessments measuring demographic, mood, subjective cognitive, Alzheimer's disease literacy, and perceived risk characteristics. Participants were categorized into four groups based on their interest: 1) want to know, 2) interested but need more information to decide, 3) unsure, 4) do not want to know).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Almost half of participants (44.2%) indicated that they had heard of\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      previously. Most participants (82%) were interested in knowing their\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      genotype or wanting more information. Compared to individuals who did not want to know their\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      genotype (114, 7.9%), individuals who wanted to know were younger, female, more likely to report dementia family history, and had greater perceived cognitive and Alzheimer's disease risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Interest in\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      disclosure is high among Australian adults, consistent with international estimates. Findings will inform\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      disclosure protocols for Australian adults at-risk of dementia.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251393714","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T18:11:11Z","timestamp":1763489471000},"page":"421-432","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Interest in apolipoprotein E (\n                    <i>APOE<\/i>\n                    ) disclosure among at-risk, cognitively unimpaired, community-dwelling Australian adults"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7600-9277","authenticated-orcid":false,"given":"Emily","family":"Rosenich","sequence":"first","affiliation":[{"name":"Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Olver","sequence":"additional","affiliation":[{"name":"Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Cummins","sequence":"additional","affiliation":[{"name":"Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Karlawish","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Medical Ethics and Health Policy, and Neurology, Perelman School of Medicine, Penn Memory Center, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0308-5156","authenticated-orcid":false,"given":"Yen Ying","family":"Lim","sequence":"additional","affiliation":[{"name":"Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2016.03.012"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540340066035"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e31821d69b8"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.2217\/fnl.10.31"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.30"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-022-01308-6"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-0059"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.02.005"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2018.35"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.231555"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004336"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.30"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0891988721993575"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/0891988705281883"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809578"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610218002089"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.119"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210675"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/14713012211067882"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-018-0398-3"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/40.1.43"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.GIM.0000132688.55591.77"},{"key":"e_1_3_5_26_2","article-title":"Early detection of Alzheimer disease: methods, markers, and misgivings","volume":"11","author":"Green R","year":"1997","unstructured":"Green R, Clarke V, Thompson N, et al. 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