{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T03:10:25Z","timestamp":1782357025503,"version":"3.54.5"},"reference-count":52,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009673","name":"Gun och Bertil Stohnes Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009673","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021594","name":"Demensfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["AF-968032"],"award-info":[{"award-number":["AF-968032"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["AF-980580"],"award-info":[{"award-number":["AF-980580"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["AF-994058"],"award-info":[{"award-number":["AF-994058"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"name":"regional agreement on medical training and clinical research of Stockholm Region","award":["FoUI-962240"],"award-info":[{"award-number":["FoUI-962240"]}]},{"name":"regional agreement on medical training and clinical research of Stockholm Region","award":["FoUI-987534"],"award-info":[{"award-number":["FoUI-987534"]}]},{"DOI":"10.13039\/501100018713","name":"Center for Innovative Medicine","doi-asserted-by":"publisher","award":["20200505"],"award-info":[{"award-number":["20200505"]}],"id":[{"id":"10.13039\/501100018713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018713","name":"Center for Innovative Medicine","doi-asserted-by":"publisher","award":["FoUI-988826"],"award-info":[{"award-number":["FoUI-988826"]}],"id":[{"id":"10.13039\/501100018713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2022-00916"],"award-info":[{"award-number":["2022-00916"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007435","name":"\u00c5ke Wiberg Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","award":["FO2021-0131"],"award-info":[{"award-number":["FO2021-0131"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","award":["FO2022-0175"],"award-info":[{"award-number":["FO2022-0175"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","award":["FO2023-0261"],"award-info":[{"award-number":["FO2023-0261"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010815","name":"Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010815","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Subjective cognitive decline (SCD) is considered an early symptom of Alzheimer's disease (AD) and other types of dementia. Establishing differences between males and females in the presentation and risk factors associated with SCD is critical for utilizing subjective cognitive assessments in prognosticating dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We performed a comprehensive review of studies examining the moderating effect of sex on the association between SCD and relevant physical and\/or mental health-related outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was performed following the PRISMA guidelines. We conducted database search in Medline, Cochrane, Web of Science (WOS), and CINAHL. Primary studies including data of the moderating effect of sex on the association between SCD and different outcomes were selected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 16 studies were included. We found limited evidence for a moderating effect of sex in SCD. Most of the available literature explored sex differences in SCD for risk of dementia, cognitive performance, competing risk of death, AD biomarkers, basal forebrain resting-state functional connectivity, brain volume, among other health outcomes. Among SCD individuals, females showed increased risk of cognitive decline, dementia and other health outcomes, whereas males showed increased risk of death and longer sickness absence compared to controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our comprehensive review denotes a lack of studies directly testing the moderating effect of sex in SCD. The available literature points to sex specific associations between SCD and multiple clinical outcomes. However, in line with the current effort of the SCD initiative, further research is necessary within this emerging topic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251397411","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T15:35:01Z","timestamp":1764344101000},"page":"604-618","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Underexplored moderating effects of sex in subjective cognitive decline: A systematic review and evidence gap"],"prefix":"10.1177","volume":"109","author":[{"given":"Yolanda","family":"\u00c1lvarez-P\u00e9rez","sequence":"first","affiliation":[{"name":"Canary Islands Health Research Institute Foundation (FIISC), El Rosario, Spain"},{"name":"Evaluation Unit (SESCS), Canary Islands Health Service (SCS), El Rosario, Spain"},{"name":"Network for Research on Chronicity, Primary Care and Health Promotion (RICAPPS), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Duarte-D\u00edaz","sequence":"additional","affiliation":[{"name":"Canary Islands Health Research Institute Foundation (FIISC), El Rosario, Spain"},{"name":"Evaluation Unit (SESCS), Canary Islands Health Service (SCS), El Rosario, Spain"},{"name":"Network for Research on Chronicity, Primary Care and Health Promotion (RICAPPS), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaiza","family":"Molina","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6521-127X","authenticated-orcid":false,"given":"Nerea","family":"Figueroa-Lamas","sequence":"additional","affiliation":[{"name":"Faculty of Psychology, University of La Laguna, San Cristobal de La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Diaz-Galvan","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (iBIS), Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2007-179X","authenticated-orcid":false,"given":"Eloy","family":"Garc\u00eda-Cabello","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2082-8481","authenticated-orcid":false,"given":"Lissett","family":"Gonzalez-Burgos","sequence":"additional","affiliation":[{"name":"Faculty of Psychology, University of La Laguna, San Cristobal de La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roraima","family":"Y\u00e1nes-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Faculty of Psychology, University of La Laguna, San Cristobal de La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5067-3196","authenticated-orcid":false,"given":"Amado","family":"Rivero-Santana","sequence":"additional","affiliation":[{"name":"Canary Islands Health Research Institute Foundation (FIISC), El Rosario, Spain"},{"name":"Evaluation Unit (SESCS), Canary Islands Health Service (SCS), El Rosario, Spain"},{"name":"Network for Research on Chronicity, Primary Care and Health Promotion (RICAPPS), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas K","family":"Olofsson","sequence":"additional","affiliation":[{"name":"Department of Psychology, Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Barroso","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden"},{"name":"Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilisbeth","family":"Perestelo-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Evaluation Unit (SESCS), Canary Islands Health Service (SCS), El Rosario, Spain"},{"name":"Network for Research on Chronicity, Primary Care and Health Promotion (RICAPPS), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1850-6451","authenticated-orcid":false,"given":"Nira","family":"Cedres","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain"},{"name":"Department of Psychology, Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Stockholm, Sweden"},{"name":"Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden"},{"name":"Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30368-0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12336"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.10.003"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.01.001"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201072"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101757"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1105620"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-022-00431-5"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/00048674221079217"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185926"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207885"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/jpr.12413"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(98)00440-7"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180720"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2013.07.002"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9885-4"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.656990"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000240048"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/0891988714524628"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glad216"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2012.08.011"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.2216"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/4946303"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/08870446.2022.2141240"},{"key":"e_1_3_3_26_2","article-title":"Recent contributions to the field of subjective cognitive decline in aging: a literature review","volume":"15","author":"Munro CE","year":"2023","unstructured":"Munro CE, Boyle R, Chen X, et al. Recent contributions to the field of subjective cognitive decline in aging: a literature review. Alzheimers Dement (Amst) 2023; 15: e12475.","journal-title":"Alzheimers Dement (Amst)"},{"key":"e_1_3_3_27_2","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Br Med J 2021; 372: n71.","journal-title":"Br Med J"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.16405"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41073-016-0007-6"},{"key":"e_1_3_3_30_2","first-page":"298","volume-title":"JBI Manual for Evidence Synthesis","author":"Moola S","year":"2020","unstructured":"Moola S, Munn Z, Tufanaru C, et al. Chapter 7: Systematic reviews of etiology and risk. In: Aromataris E, Lockwood C, Porritt K, et al. (eds) JBI Manual for Evidence Synthesis. Adelaide, South Australia: JBI, 2020, pp.298."},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215191"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010629"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018180268"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03323893"},{"key":"e_1_3_3_35_2","article-title":"In multiple facets of subjective memory decline sex moderates memory predictions","volume":"12","author":"Drouin SM","year":"2020","unstructured":"Drouin SM, McFall GP, Dixon RA. In multiple facets of subjective memory decline sex moderates memory predictions. Alzheimers Dement (Amst) 2020; 12: e12089.","journal-title":"Alzheimers Dement (Amst)"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180981"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000856"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-110428"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmedr.2020.101103"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-020-01643-1"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2015.01.008"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204436"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617707071159"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00166"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2004.11.003"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190601"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-01138-w"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2017.09.015"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03324754"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2024.105534"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.01.028"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007629920752"},{"key":"e_1_3_3_53_2","first-page":"70","article-title":"Does having regular care by a family physician improve preventive care?","volume":"47","author":"McIsaac WJ","year":"2001","unstructured":"McIsaac WJ, Fuller-Thomson E, Talbot Y. Does having regular care by a family physician improve preventive care? Can Fam Physician Med Fam Can 2001; 47: 70\u201376.","journal-title":"Can Fam Physician Med Fam Can"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251397411","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877251397411","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251397411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T10:51:11Z","timestamp":1781779871000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877251397411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/13872877251397411"],"URL":"https:\/\/doi.org\/10.1177\/13872877251397411","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,28]]}}}