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A plant known to be rich in bioactive molecules, including polyphenols, tannins, and flavonoids, sumac showed potent free radical scavenging activity. It thus may fight oxidative stress, which is recognized as the main cause of neurodegenerative ailments. In addition, recent investigations have also demonstrated during in vitro assays that Rhus coriaria might exert acetylcholinesterase inhibition activities, of interest in the context of therapeutic approaches for Alzheimer's disease (AD) associated with an increase of cholinergic neurotransmission supporting the cognitive processes. Furthermore, the sumac's neuroprotective activity may regulate amyloid-\u03b2 (A\u03b2) aggregation, an important phenomenon in the AD diseased brain. Sumac may preserve neurons and synapses by blocking A\u03b2 plaque production and neurotoxicity. That makes its anti-inflammatory activity additionally involve neuroprotective activity, largely because it reduces the pro-inflammatory cytokines level and restrains the microglial activation in the progression of AD. Given the multitarget activities, Rhus coriaria may be a potent natural candidate for preventing and treating AD. In vitro and in vivo studies are necessary to isolate its bioactive compounds, as well as preclinical and clinical studies for its effects on neurodegenerative and cognitive disorders. Dietary or medicative incorporation of sumac can supply an adjuvant choice for AD and its correlated pathogenicity.<\/jats:p>","DOI":"10.1177\/13872877251404020","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:39:02Z","timestamp":1765809542000},"page":"1053-1067","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuroprotective potential of\n                    <i>Rhus coriaria<\/i>\n                    : Insights into acetylcholinesterase inhibition and amyloid-\u03b2 modulation"],"prefix":"10.1177","volume":"109","author":[{"given":"Adeel","family":"Ahmed","sequence":"first","affiliation":[{"name":"Institute of Brain Science and Brain-inspired Research, Shandong First Medical University &amp; Shandong Academy of Medical Sciences, Jinan, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5096-7109","authenticated-orcid":false,"given":"Hamid","family":"Khan","sequence":"additional","affiliation":[{"name":"Institute of Brain Science and Brain-inspired Research, Shandong First Medical University &amp; Shandong Academy of Medical Sciences, Jinan, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Shen","sequence":"additional","affiliation":[{"name":"Institute of Brain Science and Brain-inspired Research, Shandong First Medical University &amp; Shandong Academy of Medical Sciences, Jinan, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shishi","family":"Xu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwen","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Lv","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Fu","sequence":"additional","affiliation":[{"name":"Institute of Brain Science and Brain-inspired Research, Shandong First Medical University &amp; Shandong Academy of Medical Sciences, Jinan, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0701-3122","authenticated-orcid":false,"given":"Peijun","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Brain Science and Brain-inspired Research, Shandong First Medical University &amp; Shandong Academy of Medical Sciences, Jinan, PR China"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"505","article-title":"Rhus coriaria linn, a plant of medicinal, nutritional and industrial importance: a review","volume":"22","author":"Shabbir A","year":"2012","unstructured":"Shabbir A. 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