{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:24:13Z","timestamp":1777397053032,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100030719","name":"National Institute of Health Sciences","doi-asserted-by":"publisher","award":["5R21NS077079-02"],"award-info":[{"award-number":["5R21NS077079-02"]}],"id":[{"id":"10.13039\/100030719","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>\n                    Recent epidemiological evidence showed that mutations to the HFE-63 allele of this hemochromatosis-associated iron-assimilation protein improve chances of avoiding Alzheimer's disease (AD). This is unexpected since increased brain ferroptosis in gray-matter increases the risk for vascular dementia and AD. However, diffusion tensor imaging from a key Alzheimer's Disease Neuroimaging Initiative biomarker study showed that the hemochromatosis H63D allele protected white matter tracts and improved cognitive performance in individuals when\n                    <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                    accelerates AD. H63D-carrying individuals exhibit elevated serum ferritin levels. We suggest coordinate increased levels of H-ferritin in iron-rich oligodendrocytes in H63D carriers generates sufficient neuroprotection to enhance myelin sheath integrity in white matter axons.\n                  <\/jats:p>","DOI":"10.1177\/13872877251404974","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T17:25:42Z","timestamp":1766424342000},"page":"1149-1152","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A hemochromatosis allele that protects against Alzheimer's disease injury: A role for H-ferritin"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1262-8578","authenticated-orcid":false,"given":"Jack T","family":"Rogers","sequence":"first","affiliation":[{"name":"Neurochemistry Laboratory, Department of Psychiatry-Neuroscience at Massachusetts General Hospital MGH (East), and Harvard Medical School, Charlestown, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Tsurumi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Massachusetts General Hospital, Boston, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Radiology, Massachusetts General Hospital, Boston, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changning","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Massachusetts General Hospital, Boston, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine M","family":"Cahill","sequence":"additional","affiliation":[{"name":"Neurochemistry Laboratory, Department of Psychiatry-Neuroscience at Massachusetts General Hospital MGH (East), and Harvard Medical School, Charlestown, 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