{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:24:13Z","timestamp":1777397053007,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dementia, most often due to Alzheimer's disease, is a growing concern in the Philippines. The Alzheimer's Questionnaire (AQ), an informant-based screening tool, may be particularly useful in this setting, where strong familial and caregiving ties exist. Establishing its diagnostic accuracy in Filipinos is crucial for early detection and improved care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the diagnostic accuracy of the AQ among Filipinos by comparing it with physician diagnoses and established cognitive assessment tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 190 Filipino patients who underwent cognitive assessments, including the AQ, Mini-Mental State Examination (MMSE-F), and Montreal Cognitive Assessment (MoCA-P), between 2022 and 2024. Diagnostic accuracy was measured using sensitivity, specificity, predictive values, and area under the curve (AUC). Cohen's Kappa assessed agreement between AQ classifications and physician diagnoses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Clinico-demographic analysis suggested that age and work status may influence dementia risk, while gender and common comorbidities showed no significant associations. The AQ demonstrated high specificity (92.47%) and strong diagnostic accuracy (AUC\u2009=\u20090.923) in distinguishing dementia from non-dementia, performing comparably to MoCA and MMSE. However, it was less effective in detecting mild cognitive impairment (MCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The AQ is a reliable and accurate tool for dementia screening in Filipinos, though limited for MCI detection. Incorporating AQ into routine cognitive screening may enhance early dementia identification. Further studies should refine cultural adaptations and validate its role in the Philippine healthcare context.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251405290","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T17:26:04Z","timestamp":1766424364000},"page":"1163-1173","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic accuracy of Alzheimer's Questionnaire in identifying dementia among Filipinos in a tertiary hospital"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7172-7181","authenticated-orcid":false,"given":"Keith Andrew G","family":"Ablona","sequence":"first","affiliation":[{"name":"Asian Hospital and Medical Center, Muntinlupa, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8475-3592","authenticated-orcid":false,"given":"Alvin Rae F","family":"Cenina","sequence":"additional","affiliation":[{"name":"Asian Hospital and Medical Center, Muntinlupa, Philippines"},{"name":"University of the Philippines, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-022-00338-8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12901"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-230845"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2021.628700"},{"key":"e_1_3_3_7_2","first-page":"7750235","article-title":"Validation of AD8-Philippines (AD8-P): a brief informant-based questionnaire for dementia screening in the Philippines","volume":"2021","author":"Dominguez JC","year":"2021","unstructured":"Dominguez JC, De Guzman MFP, Joson MLC, et al. Validation of AD8-Philippines (AD8-P): a brief informant-based questionnaire for dementia screening in the Philippines. Int J Alzheimers Dis 2021; 2021: 7750235.","journal-title":"Int J Alzheimers Dis"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-014-0092-z"},{"key":"e_1_3_3_9_2","article-title":"Development and validation of the Alzheimer\u2019s Questionnaire (AQ)","volume":"1","author":"Malek-Ahmadi M","year":"2015","unstructured":"Malek-Ahmadi M, Sabbagh MN. Development and validation of the Alzheimer\u2019s Questionnaire (AQ). 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Practical issues in calculating the sample size for prevalence studies. Arch Orofac Sci 2006; 1: 9\u201314.","journal-title":"Arch Orofac Sci"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0032-9"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2024.48"},{"key":"e_1_3_3_20_2","article-title":"The Alzheimer\u2019s Association clinical practice guideline for the diagnostic evaluation, testing, counseling, and disclosure of suspected Alzheimer\u2019s disease and related disorders (DETeCD-ADRD): validated clinical assessment instruments","volume":"21","author":"Atri A","year":"2025","unstructured":"Atri A, Dickerson BC, Clevenger C, et al. The Alzheimer\u2019s Association clinical practice guideline for the diagnostic evaluation, testing, counseling, and disclosure of suspected Alzheimer\u2019s disease and related disorders (DETeCD-ADRD): validated clinical assessment instruments. 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