{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:25:19Z","timestamp":1777397119045,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["STI2030-Major Projects-2022ZD0213100"],"award-info":[{"award-number":["STI2030-Major Projects-2022ZD0213100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Integrated Innovation Team Project of Shanghai Mental Health Center","award":["\/"],"award-info":[{"award-number":["\/"]}]},{"name":"The Qi Hang Talent Project of Shanghai Mental Health Center","award":["2022-QH-05"],"award-info":[{"award-number":["2022-QH-05"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) burdens patients and caregivers psychologically and emotionally. Identifying factors influencing caregivers\u2019 emotional symptoms is crucial for their mental health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigated the prevalence of depressive\/anxiety symptoms among AD caregivers and identified key influencing factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study was conducted from 2021 to 2023, involving 169 dyads of AD patients and their primary caregivers. Caregivers were assessed for depressive symptoms (HAMD &gt;7) and anxiety symptoms (HAMA &gt;6), quality of life (QoL), and dementia-related knowledge. Patients were evaluated for neuropsychiatric symptoms and cognitive function. Multivariable logistic regression and Spearman correlation analyses were used to identify key influencing factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 169 caregivers (mean age 56.97\u2009\u00b1\u200914.19 years, 62.13% female), depressive and anxiety symptom incidence was 24.85% and 25.44% (comorbidity 13.6%). Better dementia knowledge (\u201cRisk\/Health Promotion\": OR\u2009=\u20090.79, 95% CI: 0.67\u20130.93; \u201cCare Precautions\": OR\u2009=\u20090.81, 95% CI: 0.69\u20130.95) was protective against caregiver depressive symptoms, while patient anxiety symptoms (OR\u2009=\u20091.09, 95% CI: 1.01\u20131.17) and sleep\/night problems (OR\u2009=\u20091.14, 95% CI: 1.05\u20131.24) increased risk. Increased caregiver age was protective against caregiver anxiety symptoms (OR\u2009=\u20090.94, 95% CI: 0.9\u20130.97), but patient anxiety symptoms (OR\u2009=\u20091.10, 95% CI: 1.03\u20131.18) and caregivers\u2019 lower QoL (OR\u2009=\u20091.10, 95% CI: 1.01\u20131.19) were risk factors. Furthermore, caregivers\u2019 HAMD scores were negatively correlated with dementia knowledge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Depressive\/anxiety symptoms are common in AD caregivers, influenced by patient anxiety, sleep issues, caregiver age, QoL, and dementia knowledge. Targeted interventions to support caregiver mental health and knowledge are crucial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251405492","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T17:26:48Z","timestamp":1766424408000},"page":"1264-1273","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Influencing factors of depressive and anxiety symptoms among caregivers of Alzheimer's disease patients: A cross-sectional study"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2971-9549","authenticated-orcid":false,"given":"Chengfei","family":"Duan","sequence":"first","affiliation":[{"name":"Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Department of Psychiatry and Psychology, The Eighth People's Hospital of Zhengzhou, Henan, China"},{"name":"Department of Psychiatry and Psychology, The Mental Health Center of Zhengzhou, Henan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2731-0366","authenticated-orcid":false,"given":"Mo","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6476-0189","authenticated-orcid":false,"given":"Ling","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00249-8"},{"key":"e_1_3_3_4_2","article-title":"The China Alzheimer report 2022","volume":"35","author":"Ren R","year":"2022","unstructured":"Ren R, Qi J, Lin S, et al. 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