{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T10:14:34Z","timestamp":1779272074535,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Increasing numbers of studies indicate that the pathophysiological progression of Alzheimer's disease (AD) could be accelerated by chronic cerebral hypoperfusion (CCH). These findings suggest that cerebrovascular dysfunction may induce cognitive impairment in AD by expediting neurodegeneration.\n                      <jats:italic toggle=\"yes\">Dendrobium nobile<\/jats:italic>\n                      Lindl. alkaloids (DNLA), the primary active components of\n                      <jats:italic toggle=\"yes\">Dendrobium nobile<\/jats:italic>\n                      Lindl., have been shown to enhance cognitive function and exhibit neuroprotective effects in AD animal models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>However, the impact of DNLA on AD with CCH is still elusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we explored the therapeutic potential and underlying mechanisms of DNLA using a novel AD plus CCH mouse model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results demonstrate that DNLA significantly improved cerebral blood flow, attenuated motor and cognitive decline, reduced amyloid-\u03b2 deposition, mitigated neuroinflammation, and alleviated neural oxidative stress in 12-month-old AD mice with CCH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study suggests that DNLA exerts multiple neuroprotective effects, effectively preserving motor and cognitive function in AD with CCH mice of 12 months. Thus, DNLA represents a promising therapeutic candidate for the prevention and treatment of AD plus CCH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251406645","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T17:29:22Z","timestamp":1766424562000},"page":"1405-1414","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Protective effects of\n                    <i>Dendrobium nobile<\/i>\n                    Lindl. alkaloids in a novel mouse model of Alzheimer's disease with chronic cerebral hypoperfusion"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7924-8583","authenticated-orcid":false,"given":"Tian","family":"Feng","sequence":"first","affiliation":[{"name":"Center for Tissue Engineering and Stem Cell Research, Guizhou Medical University, Guiyang, China"},{"name":"Department of Cardiovascular Surgery, the Affiliated Hospital of Guizhou Medical University, Guiyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8281-9456","authenticated-orcid":false,"given":"Wang","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Tissue Engineering and Stem Cell Research, Guizhou Medical University, Guiyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1715-2943","authenticated-orcid":false,"given":"Zhihong","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Neurology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2199-3489","authenticated-orcid":false,"given":"Hongming","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2643-2536","authenticated-orcid":false,"given":"Lianhua","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Zunyi Medical University, Zunyi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01249-0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38878-8"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209801"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac228"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160345"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190369"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20968927"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215246"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2024.148790"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci14030231"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X19666210809101945"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.324824"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-151126"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.06.003"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20246176"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.24.13287"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06915.x"},{"key":"e_1_3_3_19_2","volume-title":"Medical statistics A commonsense approach: a textbook for health science","author":"Machin D","year":"2007","unstructured":"Machin D, Campbell MJ. 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