{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:25:00Z","timestamp":1777397100560,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The association between open-angle glaucoma (OAG) and early-onset Alzheimer's disease (EOAD) remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between OAG and EOAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a case-control study using a Japanese nationwide administrative claims database. Individuals aged 40\u201364 with a diagnosis of Alzheimer's disease (AD) and a prescription for AD medications were defined as EOAD cases (n\u2009=\u20092344). The index date was the first AD medication prescription. Controls (n\u2009=\u20099376) were matched to cases in a 4:1 ratio by age and sex using risk set sampling. OAG exposure was defined as a diagnosis \u226512 months before the index date. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>OAG was present in 15.8% of EOAD cases and 12.5% of controls. A significant association was observed between OAG and EOAD (OR, 1.22; 95% CI, 1.06\u20131.40; p\u2009=\u20090.006). EOAD was associated with diabetes (OR, 1.56; 95% CI, 1.37\u20131.77; p\u2009&lt;\u20090.001), hypertension (OR, 1.15; 95% CI, 1.02\u20131.29; p\u2009=\u20090.021), depression (OR, 7.81; 95% CI, 6.76\u20139.02; p\u2009&lt;\u20090.001), and excessive alcohol use (OR, 2.35; 95% CI, 1.72\u20133.21; p\u2009&lt;\u20090.001). In sex-stratified analyses, the association between OAG and EOAD was significant in males (OR, 1.32; 95% CI, 1.09\u20131.60; p\u2009=\u20090.005) but not in females (OR, 1.11; 95% CI, 0.90\u20131.37; p\u2009=\u20090.321).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Individuals with OAG may be associated with an increased risk of EOAD, and careful monitoring of cognitive symptoms may help facilitate early detection and intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251410501","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T17:03:58Z","timestamp":1767027838000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between open angle glaucoma and early onset Alzheimer's disease"],"prefix":"10.1177","volume":"110","author":[{"given":"Yuto","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Bunkyo, Japan"},{"name":"Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, Shimane, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuaki","family":"Michihata","sequence":"additional","affiliation":[{"name":"Cancer Prevention Center, Chiba Cancer Center Research Institute, Chiba, Japan"},{"name":"Department of Health Services Research, Graduate School of Medicine, The University of Tokyo, Bunkyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Tanito","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, Shimane, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimune","family":"Hiratsuka","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Bunkyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Nakao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Bunkyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Yasunaga","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Bunkyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"World Health Organization. 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