{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:21:54Z","timestamp":1793384514619,"version":"4.5.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG05854901"],"award-info":[{"award-number":["R01AG05854901"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R37AG023651"],"award-info":[{"award-number":["R37AG023651"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["2U24NS107166-06"],"award-info":[{"award-number":["2U24NS107166-06"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sedentary behavior is common in older adulthood and is associated with poor health outcomes. Less is known about how sedentary behavior relates to cognition in older adulthood and how it relates to increased risk for cognitive decline associated with Alzheimer's disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We sought to examine these associations in a large, population-based cohort of community-dwelling older adults residing in a Rust Belt region of the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A subset of the population-based Monongahela\u2013Youghiogheny Healthy Aging Team (MYHAT) participants (n\u2009=\u2009193) completed 7 days of wrist-accelerometry following comprehensive neuropsychological assessment. Cross-sectional linear regression models related sedentary time to domains of cognition. Models were adjusted by age, sex, education, and\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      carrier status and moderate to vigorous physical activity (MVPA). The interaction between sedentary behavior and\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      genotype on cognition was also examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Greater sedentary behavior was associated with worse executive function (\u03b2\u2009=\u2009\u22120.06,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.01) and memory (\u03b2\u2009=\u2009\u22120.06,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.05) performance. These results were attenuated when adjusting for MVPA. No significant interactions between sedentary time and\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      carrier status were observed, although estimation results applying the delta method on regression coefficients suggested the associations were stronger in\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      non-carriers when compared to\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      carriers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher levels of sedentary behavior were associated with worse performance in cognitive domains implicated in AD. Public health initiatives and precision-based medicine approaches to reduce sedentary behavior in a population-based cohort of older adults may be important AD prevention measures. Results support the importance of reducing sedentary time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251410964","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T13:40:28Z","timestamp":1769089228000},"page":"1815-1823","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The associations between sedentary behavior and cognition in a population cohort of older adults"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8331-693X","authenticated-orcid":false,"given":"Marissa A","family":"Gogniat","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Chou H","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA"},{"name":"Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Storey","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Carper","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Ilyas","family":"Kamboh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"},{"name":"Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann D","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Ganguli","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"},{"name":"Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"},{"name":"Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Snitz","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002751"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.15231"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-037475"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-014-0522-0"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-020-01521-y"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047831"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-019-01460-8"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx273"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70157"},{"key":"e_1_3_4_11_2","first-page":"12","article-title":"Association between sedentary behavior and the risk of dementia: a systematic review and meta-analysis","volume":"10","author":"Yan S","year":"2020","unstructured":"Yan S, Fu W, Wang C, et al. 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