{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:24:31Z","timestamp":1787059471955,"version":"build-2736575974"},"reference-count":46,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG072977"],"award-info":[{"award-number":["P30AG072977"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Lieber Institute for Brain Development (LIBD) has one of the largest postmortem human brain banks for the study of neuropsychiatric disorders in the world. The postmortem evaluation involves neuropathological assessment for age-related protein accumulations, specifically phosphorylated tau (p-tau) and amyloid-\u03b2 (A\u03b2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Present the LIBD semiquantitative assessment methodology for p-tau and A\u03b2 by comparing proteinopathy by age and by apolipoprotein E (\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      ) genotype.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Postmortem brain tissue samples were from 1509 people aged 50 or greater (median age at death\u2009=\u200963 years; range\u2009=\u200950\u2013102). Seven brain regions (four neocortical areas, hippocampal formation, midbrain, and cerebellum) were examined by routine histopathology, p-tau immunohistochemistry (AT8; hippocampus and four neocortical samples), and A\u03b2 immunohistochemistry (BAM01; four neocortical samples).\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      genotyping was performed in a subgroup. Semiquantitative assessments include modified CERAD (Consortium to Establish a Registry for Alzheimer's Disease) and modified Braak approaches.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 63.8% rated as B1 (modified Braak I or II), 30.4% rated as B2 (modified Braak III or IV), and 5.8% rated as B3 (modified Braak V or VI). For those in their early 70\u2005s, half had modified Braak stage III-IV ratings. For decedents in their 80\u2005s, approximately 1 in 4 had modified Braak stage V-VI ratings. A\u03b2 was present in 48.8% (C0\u2009=\u200951.2%, C1\u2009=\u200917.2%, C2\u2009=\u200924.5%, and C3\u2009=\u20097.1%). Age and\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      genotype were significant predictors of A\u03b2 plaques.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The LIBD protocol assessing p-tau and A\u03b2 burden identified significant associations with age and\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      genotype. More research is needed to understand the spectrum of age-related proteinopathy versus neurodegenerative disease neuropathology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251411332","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T12:02:14Z","timestamp":1768996934000},"page":"1858-1873","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Hyperphosphorylated tau and amyloid-\u03b2 proteinopathy in people over age 50: Findings from the Lieber Institute for Brain Development Brain Donation Repository"],"prefix":"10.1177","volume":"109","author":[{"given":"Rudolph J.","family":"Castellani","sequence":"first","affiliation":[{"name":"Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul 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