{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:26:28Z","timestamp":1777397188731,"version":"3.51.4"},"reference-count":55,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Sichuan Science and Technology Program","award":["2022YFS0422"],"award-info":[{"award-number":["2022YFS0422"]}]},{"name":"Sichuan Science and Technology Program","award":["2023NSFSC1736"],"award-info":[{"award-number":["2023NSFSC1736"]}]},{"name":"Sichuan Science and Technology Program","award":["2024NSFSC0490"],"award-info":[{"award-number":["2024NSFSC0490"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cognitive impairment is increasingly prevalent in younger populations. The interplay between environmental exposures like noise and genetic susceptibility in dementia etiology remains unclear. This study investigated the combined effects of work-related cumulative noise exposure (WCNE) and genetic polymorphisms on cognitive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the relationships among WCNE, genetic factors (APOE rs429358\/rs7412 and PS-1 rs165932), and lower cognitive performance (LCP), and to analyze the potential interaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 523 workers from a health surveillance cohort in western China. WCNE was assessed for each participant. Genotyping was performed for APOE (rs429358\/rs7412) and PS-1 (rs165932) polymorphisms. Cognitive function was evaluated via Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). The individual and combined effects of WCNE and genetic factors on LCP were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>APOE rs429358\/rs7412 were not significantly associated with LCP. The PS-1 rs165932T allele (PS-1T) was associated with LCP (p\u2009&lt;\u20090.05). The adjusted odds ratios (aORs) for LCP (evaluated by MMSE and MoCA) in the PS-1T group were 2.443 (95% CI: 1.149\u20135.195) and 2.065 (95% CI: 1.091\u20133.906), respectively. Age and WCNE had an interaction effect on the LCP for both MMSE and MoCA (p\u2009&lt;\u20090.05), while PS-1T had an effect modification on the relationship between WCNE and LCP (p\u2009&lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings highlight the urgent need to identify and mitigate noise exposure risks in vulnerable populations. These findings also provide evidence for further mechanistic studies exploring how noise, aging, and genetic susceptibility contribute to cognitive impairment through underlying biological mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877251413707","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:35:47Z","timestamp":1770042947000},"page":"120-132","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of work-related noise exposure with cognitive performance: Effect modification by PS-1 rs165932"],"prefix":"10.1177","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3609-0795","authenticated-orcid":false,"given":"Lei","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Postgraduate Students, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shushan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajia","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Occupational Medicine, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Postgraduate Students, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Periodical Press and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China"},{"name":"Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"377","article-title":"Epidemiology of Alzheimer's disease and other dementias","volume":"66","author":"Garre-Olmo J","year":"2018","unstructured":"Garre-Olmo J. Epidemiology of Alzheimer's disease and other dementias. Rev Neurol 2018; 66: 377\u2013386.","journal-title":"Rev Neurol"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12074"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0892-345"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.07.032"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.49.31025"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410106"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.4.611"},{"key":"e_1_3_3_9_2","first-page":"190","article-title":"The interactive effect of occupational noise on attention and short-term memory: a pilot study","volume":"20","author":"Monteiro R","year":"2018","unstructured":"Monteiro R, Tom\u00e9 D, Neves P, et al. The interactive effect of occupational noise on attention and short-term memory: a pilot study. Noise Health 2018; 20: 190\u2013198.","journal-title":"Noise Health"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2025.1455340"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16101790"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2017.03.018"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12191"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01296-0"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01406-X"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201037"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2019.108537"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.08.025"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2002.0483"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp058027"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91140-X"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)00653-8"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990205)88:1<1::AID-AJMG1>3.0.CO;2-N"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161212799315795"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32948-4"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1223-4"},{"key":"e_1_3_3_27_2","first-page":"2721","article-title":"Preliminary discussion and application of occupation-related cumulative noise exposure assessment method","volume":"50","author":"Jing Z","year":"2023","unstructured":"Jing Z, Jing-xuan M, Yong-wei W, et al. Preliminary discussion and application of occupation-related cumulative noise exposure assessment method. Modern Prev Med 2023; 50: 2721\u20132725.","journal-title":"Modern Prev Med"},{"key":"e_1_3_3_28_2","first-page":"4","article-title":"Application of the Chinese version of Mini-Mental State Examination (MMSE)","volume":"7","author":"Zhengyu W","year":"1989","unstructured":"Zhengyu W, Mingyuan Z. Application of the Chinese version of Mini-Mental State Examination (MMSE). Shanghai Arch Psychiatry 1989; 7: 4.","journal-title":"Shanghai Arch Psychiatry"},{"key":"e_1_3_3_29_2","first-page":"3","article-title":"Application of Montreal Cognitive Assessment Scale in screening patients with mild cognitive impairment","volume":"46","author":"Wei W","year":"2007","unstructured":"Wei W, Luning W. Application of Montreal Cognitive Assessment Scale in screening patients with mild cognitive impairment. Chin J Intern Med 2007; 46: 3.","journal-title":"Chin J Intern Med"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_3_3_32_2","first-page":"166","article-title":"Expert consensus on clinical application of commonly used neuropsychological cognitive assessment scales","volume":"52","author":"Neuropsychological and Behavioral Neurology Group","year":"2019","unstructured":"Neuropsychological and Behavioral Neurology Group. Expert consensus on clinical application of commonly used neuropsychological cognitive assessment scales. Chin J Neurol 2019; 52: 166\u2013176.","journal-title":"Chin J Neurol"},{"key":"e_1_3_3_33_2","first-page":"269","article-title":"Chinese Guidelines for the diagnosis and treatment of Alzheimer's disease and dementia (2020 edition)","volume":"40","author":"Tian JZ","year":"2021","unstructured":"Tian JZ, Xie HG, Wang LN, et al. Chinese Guidelines for the diagnosis and treatment of Alzheimer's disease and dementia (2020 edition). Chin J Geriatr 2021; 40: 269\u2013283.","journal-title":"Chin J Geriatr"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr218"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.10.1016"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-005-7835-x"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.01.012"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.02.013"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566523220666201123112822"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.04.001"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-05948-6"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-240061"},{"key":"e_1_3_3_43_2","first-page":"5906","article-title":"Research progress on the pathogenesis of Alzheimer's disease","author":"Xianhui D","year":"2014","unstructured":"Xianhui D, Xiqing C. Research progress on the pathogenesis of Alzheimer's disease. Chin J Gerontol 2014; 20: 5906\u20135912.","journal-title":"Chin J Gerontol"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197174"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202894"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.3109\/08923973.2012.705292"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09799-6"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2024.109033"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.2174\/1567205018666210324114153"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.175879"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306957200"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02982587"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22363"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.07.049"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1539\/joh.L8084"},{"key":"e_1_3_3_56_2","first-page":"163","article-title":"Effect of chronic noise exposure on expression of N-methyl-D-aspartic acid receptor 2B and Tau phosphorylation in hippocampus of rats","volume":"26","author":"Cui B","year":"2013","unstructured":"Cui B, Wu MQ, Zhu LX, et al. Effect of chronic noise exposure on expression of N-methyl-D-aspartic acid receptor 2B and Tau phosphorylation in hippocampus of rats. Biomed Environ Sci 2013; 26: 163\u2013168.","journal-title":"Biomed Environ Sci"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251413707","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877251413707","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877251413707","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:10:03Z","timestamp":1777371003000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877251413707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,2]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1177\/13872877251413707"],"URL":"https:\/\/doi.org\/10.1177\/13872877251413707","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,2]]}}}