{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:37:39Z","timestamp":1792795059508,"version":"4.5.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"AIIMS new delhi","award":["AIIMS intramural grants (F.8.55\/AC-55\/2023\/RS; F.8"],"award-info":[{"award-number":["AIIMS intramural grants (F.8.55\/AC-55\/2023\/RS; F.8"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Alzheimer's disease (AD) is marked by cognitive decline, depressive symptoms, and gut microbial dysbiosis. Yoga may support cognitive and emotional health while modulating gut microbiota, but integrative clinical evidence is limited\n                      <jats:bold>.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effects of a 12-week yoga intervention on cognition, depressive symptoms, and gut microbial diversity, composition, and function in Indian patients with mild AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this hospital-based case-control study, 16 AD patients and 17 cognitively healthy controls (HCs) were recruited at AIIMS, New Delhi. AD diagnosis followed NIA-AA criteria, supported by Montreal Cognitive Assessment (MoCA) and Patient Health Questionnaire-9 (PHQ-9) assessments. AD participants underwent 60-min supervised yoga sessions daily for 12 weeks. Cognitive performance, depressive symptoms, and stool microbiota were assessed pre- and post-intervention. Metagenomic sequencing enabled taxonomic and functional profiling, with alpha diversity, beta diversity (Bray-Curtis distance), and differential abundance analyses performed using standard bioinformatics tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Yoga was associated with improved cognition (MoCA: 22.33\u2009\u00b1\u20092.34\u2009\u2192\u200925.44\u2009\u00b1\u20092.01;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001) and reduced depressive symptoms (PHQ-9: 5.78\u2009\u00b1\u20093.11\u2009\u2192\u20092.22\u2009\u00b1\u20091.71;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.007). Alpha diversity remained stable, while beta diversity shifted post-yoga AD samples toward the HC cluster. Beneficial taxa (\n                      <jats:italic toggle=\"yes\">Faecalibacterium prausnitzii<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Roseburia intestinalis<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Bifidobacterium<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Akkermansia<\/jats:italic>\n                      ) increased, whereas pro-inflammatory taxa (\n                      <jats:italic toggle=\"yes\">Collinsella aerofaciens<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Klebsiella<\/jats:italic>\n                      spp.) decreased. Functional analysis showed partial recovery of metabolic and short-chain fatty acid pathways.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A 12-week yoga intervention was associated with cognitive and mood improvements and partial normalization of gut microbial function in mild AD. Larger randomized trials with lifestyle monitoring and multi-omics integration are warranted to confirm causal mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261415612","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:34:50Z","timestamp":1769600090000},"page":"562-575","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of yoga with cognitive and gut microbiome changes in Alzheimer's disease: An exploratory case-control study"],"prefix":"10.1177","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6418-8928","authenticated-orcid":false,"given":"Prabhakar","family":"Tiwari","sequence":"first","affiliation":[{"name":"Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Kaushik","sequence":"additional","affiliation":[{"name":"Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekha","family":"Dwivedi","sequence":"additional","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjari","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima","family":"Dada","sequence":"additional","affiliation":[{"name":"Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13601-y"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180176"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0157-3"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1481390"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu15214631"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1422350"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201497"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.3790"},{"key":"e_1_3_3_10_2","first-page":"273","article-title":"The gut microbiome in health and disease in relation to metabolic function and yoga as a potential therapeutic approach in restoring dysbiosis","volume":"11","author":"Krishna A","year":"2024","unstructured":"Krishna A, Sharma KK. 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