{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:41:36Z","timestamp":1790257296353,"version":"4.1.0"},"reference-count":57,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100007132","name":"Otsuka Pharmaceutical Co., Ltd.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007132","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer's disease (AD) may seriously impact caregiver burden and, therefore, quality of care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To clarify the association of BPSD and BPSD subtypes with caregiver burden and quality of life (QOL) among caregivers of patients with AD in Japan in a multidimensional manner.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This descriptive, cross-sectional, community-based survey involved administering a web-based questionnaire to live-in caregivers of patients with AD registered with Macromill Inc. BPSD prevalence was measured using the Japanese version of the Neuropsychiatric Inventory-Questionnaire Form. The Japanese version of the Zarit Caregiver Burden Scale (J-ZBI), EQ-5D-5L, and Adult Social Care Outcomes Toolkit for Carers (ASCOT-Carer) were used to assess caregiver burden, health-related QOL, and social care-related QOL, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 705 survey responders, 639 (90.6%) and 66 (9.4%) cared for patients with and without BPSD, respectively. Mean caregiver age was 54.6 years, 56.9% were male, and 84.0% cared for parents or in-laws. In the \u201cwith BPSD\u201d group, the J-ZBI score was higher (mean difference [95% confidence interval], 6.7 [4.5, 9.0];\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while EQ-5D-5L and ASCOT-Carer scores were lower (\u20130.076 [\u20130.134, \u22120.018;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.010] and \u22120.101 [\u20130.168, \u22120.033];\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.003, respectively) than in the \u201cwithout BPSD\u201d group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A significant association between increased caregiver burden and BPSD in patients with AD was demonstrated, which may be associated with decreased caregiver healthcare and social care-related QOL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261415637","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:34:50Z","timestamp":1769600090000},"page":"628-638","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Caregiver burden and quality of life associated with behavioral and psychological symptoms of Alzheimer's disease: A web-based cross-sectional survey study"],"prefix":"10.1177","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5952-6141","authenticated-orcid":false,"given":"Shunichiro","family":"Shinagawa","sequence":"first","affiliation":[{"name":"Department of Psychiatry, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8731-9887","authenticated-orcid":false,"given":"Tomoyuki","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan"},{"name":"Center for Dementia-Related Diseases, Airanomori Hospital, Yusui-cho aira-gun, Kagoshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6952-7770","authenticated-orcid":false,"given":"Shinichi","family":"Noto","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Niigata University of Health and Welfare, Niigata-shi, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5027-6289","authenticated-orcid":false,"given":"Kentaro","family":"Yamato","sequence":"additional","affiliation":[{"name":"Medical Affairs, Otsuka Pharmaceutical Co., Ltd., Tokyo, Japan"},{"name":"Department of Public Health, Graduate School of Medicine, Juntendo University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9948-5260","authenticated-orcid":false,"given":"Naoki","family":"Mori","sequence":"additional","affiliation":[{"name":"Medical Affairs, Otsuka Pharmaceutical Co., Ltd., Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6395-5275","authenticated-orcid":false,"given":"Keisuke","family":"Onuki","sequence":"additional","affiliation":[{"name":"Medical Affairs, Otsuka Pharmaceutical Co., Ltd., Tokyo, Japan"},{"name":"Department of Public Health, Graduate School of Medicine, Juntendo University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.937486"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2023.2291966"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.4306\/pi.2016.13.1.43"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/13607863.2016.1146871"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.114.148403"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2014.12.018"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4704"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1267"},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1177\/140349480002800106","article-title":"Family caregiving in dementia\u2014an analysis of the caregiver\u2019s burden and the \u201cbreaking-point\u201d when home care becomes inadequate","volume":"28","author":"Annerstedt L","year":"2000","unstructured":"Annerstedt L, Elmst\u00e5hl S, Ingvad B, et al. 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