{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:09:58Z","timestamp":1778670598951,"version":"3.51.4"},"reference-count":52,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Korean ARPA-H Project","award":["RS-2024-00512374"],"award-info":[{"award-number":["RS-2024-00512374"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early detection of Alzheimer's disease (AD) is critical for effective disease management and treatment. Web-based assessment tools offer advantages by enabling broader accessibility and reducing reliance on specialized clinical infrastructure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to validate a self-administered, web-based cognitive assessment tool for AD screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 106 older adults aged 55 to 84 years were recruited and clinically classified as cognitively unimpaired (CU, n\u2009=\u200935), amnestic mild cognitive impairment (aMCI, n\u2009=\u200937), or AD (n\u2009=\u200934). Participants completed Cogscreen, a 10-min web-based cognitive test comprising verbal cued memory and digit symbol substitution tasks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both the verbal cued memory and digit symbol substitution tasks showed significant score differences among CU, aMCI, and AD (p\u2009&lt;\u20090.001). The Cogscreen composite score yielded area under the curve (AUC) values of 0.876 for aMCI (cut-off\u2009=\u20090.64, sensitivity\u2009=\u20090.865, specificity\u2009=\u20090.657) and 0.994 for AD (cut-off\u2009=\u2009\u22120.59, sensitivity\u2009=\u20090.971, specificity\u2009=\u20090.971), and outperformed the Mini-Mental State Examination (MMSE) in diagnosing aMCI (AUC\u2009=\u20090.638, p\u2009=\u20090.001). The composite score significantly correlated with the Consortium to Establish a Registry for Alzheimer's Disease assessment packet total score (r\u2009=\u20090.765, p\u2009&lt;\u20090.001) and MMSE score (r\u2009=\u20090.722, p\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cogscreen is a rapid, self-administered cognitive screening tool for detecting aMCI and AD. It outperforms the MMSE in identifying early cognitive decline and holds potential for detecting even subtler cognitive changes in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261415925","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:34:50Z","timestamp":1769600090000},"page":"639-648","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Validation of a web-based cognitive test for early detection of Alzheimer's disease"],"prefix":"10.1177","volume":"110","author":[{"given":"Jeong Hyeon","family":"Byeon","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dasom","family":"Lee","sequence":"additional","affiliation":[{"name":"Research and Development Team, Emocog Inc., Gwacheon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Ji","family":"Shin","sequence":"additional","affiliation":[{"name":"Research and Development Team, Emocog Inc., Gwacheon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Mi","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Jin","family":"Yoon","sequence":"additional","affiliation":[{"name":"Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeonjin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunsun","family":"Ham","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyoon","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanik","family":"Yoo","sequence":"additional","affiliation":[{"name":"Seoul Brain Research Institute, Seoul, Republic of Korea"},{"name":"Department of Teacher Education, College of Education, Konkuk University, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hae","family":"Youn","sequence":"additional","affiliation":[{"name":"Graduate School of Clinical Counseling Psychology, CHA University, Pocheon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Hee","family":"Kang","sequence":"additional","affiliation":[{"name":"Executive Management, Happymind Inc., Gwacheon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea"},{"name":"Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"World Health Organization. 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