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Non-invasive photobiomodulation therapy (PBM) is a promising intervention that has been shown to reduce amyloid and tau pathology, improve synaptic function, and preserve hippocampal neurogenesis in animal models of AD. Nano-pulsed laser therapy (NPLT) is a type of PBM therapy using pulsed 808\u2005nm near-infrared laser light and optoacoustically generated ultrasound waves to stimulate deeper brain structures than would be accessible by traditional PBM therapy. We hypothesize that NPLT can effectively modulate hippocampal neurogenesis to induce resilience against AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess resilience of hippocampal neurons derived from NPLT-treated neural stem cells (NSC) against A\u03b2O toxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We use NPLT to stimulate adult hippocampal neural stem cells (NSC) then induce neuronal differentiation in vitro and assess the mature neurons for A\u03b2O binding capacity and mitochondrial toxicity, and gene expression changes after NPLT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that neurons differentiated from NPLT-treated NSC are resilient against A\u03b2O binding and mitochondrial toxicity, and show increased expression of genes associated with autophagy and proteostasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings support the hypothesis that NPLT modulation of hippocampal neurogenesis can be an effective non-invasive approach to induce resilience against AD toxic oligomers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261416086","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:34:50Z","timestamp":1769600090000},"page":"705-715","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Treating hippocampal neural stem cells with nano-pulsed laser therapy generates neurons resilient against amyloid-\u03b2 oligomer toxicity"],"prefix":"10.1177","volume":"110","author":[{"given":"Kevin","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, The University of Texas Medical Branch at Galveston, Galveston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auston","family":"Grant","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The University of Texas Medical Branch at Galveston, Galveston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrinath","family":"Kadamangudi","sequence":"additional","affiliation":[{"name":"The Mitchell Center for Neurodegenerative Disorders, Department of Neurology, The University of Texas Medical Branch at Galveston, Galveston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Arizpe","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The University of Texas Medical Branch at Galveston, 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