{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:36:10Z","timestamp":1792787770791,"version":"4.5.0"},"reference-count":49,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Zhou Liu","award":["2024A1515220002, 4SG23284G, 2024HY-A6006, 4SG22307"],"award-info":[{"award-number":["2024A1515220002, 4SG23284G, 2024HY-A6006, 4SG22307"]}]},{"name":"De Cai","award":["LCYJ2020B009"],"award-info":[{"award-number":["LCYJ2020B009"]}]},{"name":"Shaoping Zhu","award":["2020B01395"],"award-info":[{"award-number":["2020B01395"]}]},{"name":"Yinwen Xu","award":["2022B01004"],"award-info":[{"award-number":["2022B01004"]}]},{"name":"Li Hu","award":["2020B01421\uff0cGDMUQ2021047"],"award-info":[{"award-number":["2020B01421\uff0cGDMUQ2021047"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dysbiosis of gut microbiota and increased intestinal permeability are associated with various diseases, and their relationship with cognitive dysfunction such as cerebral small vessel disease (CSVD) and Alzheimer's disease remains to be elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigates the role of gut microbiota dysbiosis and its relationship with intestinal permeability in patients with cognitive impairment associated with CSVD (CSVD-CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Intestinal permeability was detected in 21 patients with CSVD-CI and 20 healthy controls by testing urine lactulose\/mannitol, and correlation analysis was performed between the test results and cognitive function assessment. 16S rRNA sequencing was used to analyze the different combination of gut microbiota. Feces of the patients or controls were gavaged into C57 mice, and gut barrier function, behavior, and metabolites were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with CSVD-CI have a higher incidence of hypertension, higher homocysteine levels, higher scores for white matter hyperintensities, and worse cognitive function. Their urinary mannitol recovery rate is higher, which is correlated with lower scores of cognitive function assessment. Alterations in the gut microbiota involve a reduction in\n                      <jats:italic toggle=\"yes\">Prevotella-9<\/jats:italic>\n                      alongside increases in\n                      <jats:italic toggle=\"yes\">Proteobacteria<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Fusobacteria<\/jats:italic>\n                      . Fecal microbiota transplantation (FMT) from patients with CSVD-CI increases intestinal permeability in mice, but does not change their cognitive function; meanwhile, fecal metabolomics analysis has identified alterations in bile acids and vitamins, which are associated with shifts in the gut microbiota.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with CSVD-CI have gut microbiota imbalance and increased intestinal permeability, which are associated with cognitive decline. FMT from these patients can cause intestinal leakage and the production of harmful metabolites in mice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261418554","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T06:59:55Z","timestamp":1772261995000},"page":"922-936","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Correlation study between gut microbiota and intestinal permeability in cerebral small vessel disease"],"prefix":"10.1177","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4318-0691","authenticated-orcid":false,"given":"Yating","family":"Chen","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Guangdong Medical 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